Rv0352

Tuberculist information
Gene namednaJ1
Protein functionProbable chaperone protein DnaJ1
Functional category(tuberculist)virulence,detoxification and adaptaion
Gene location(kb)422.452
Molecular mass(da)41345.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 395
	  		  	1    MAQREWVEKDFYQELGVSSDASPEEIKRAYRKLARDLHPDANPGNPAAGERFKAVSEAHN   60
			  	61   VLSDPAKRKEYDETRRLFAGGGFGGRRFDSGFGGGFGGFGVGGDGAEFNLNDLFDAASRT  120
			  	121  GGTTIGDLFGGLFGRGGSARPSRPRRGNDLETETELDFVEAAKGVAMPLRLTSPAPCTNC  180
			  	181  HGSGARPGTSPKVCPTCNGSGVINRNQGAFGFSEPCTDCRGSGSIIEHPCEECKGTGVTT  240
			  	241  RTRTINVRIPPGVEDGQRIRLAGQGEAGLRGAPSGDLYVTVHVRPDKIFGRDGDDLTVTV  300
			  	301  PVSFTELALGSTLSVPTLDGTVGVRVPKGTADGRILRVRGRGVPKRSGGSGDLLVTVKVA  360
			  	361  VPPNLAGAAQEALEAYAAAERSSGFNPRAGWAGNR

Known structures in the PDB
No Known structures
1 40 79 118 157 196 235 274 313 352 391 Range: 10 to 72  |  Coverage: 15% DnaJ Range: 177 to 237  |  Coverage: 15% DnaJ_CXXCXGXG Range: 295 to 373  |  Coverage: 19% DnaJ_C Range: 8 to 81  |  Coverage: 18% 1 Range: 4 to 85  |  Coverage: 20% 2 Range: 8 to 95  |  Coverage: 22% 3 Range: 148 to 374  |  Coverage: 57% 4 Range: 177 to 237  |  Coverage: 15% 1 Range: 1 to 56  |  Coverage: 13% 2 Range: 10 to 72  |  Coverage: 15% 3 Range: 235 to 290  |  Coverage: 13% 4 Range: 295 to 350  |  Coverage: 13% 5
Number of amino acids : 395
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
DnaJPF0022610-72
DnaJ_CXXCXGXGPF00684177-237
DnaJ_CPF01556295-373
Mtb Structural Proteome models
Model Number1
Model nameRv0352.2
Template2CTP    APDBCREDO
Template coverage6_78
Template Identity(%)49.3
Model coverage(%)18.5
Normalized DOPE score-2.024

Model Number2
Model nameRv0352.1
Template2CTQ    APDBCREDO
Template coverage15_96
Template Identity(%)31.7
Model coverage(%)20.5
Normalized DOPE score-1.528

Model Number3
Model nameRv0352.3
Template2CTR    APDBCREDO
Template coverage6_88
Template Identity(%)39.8
Model coverage(%)22.0
Normalized DOPE score-1.287

Model Number4
Model nameRv0352
Template1C3G    APDBCREDO
Template coverage180_349
Template Identity(%)24.7
Model coverage(%)57.2
Normalized DOPE score0.727

Structure Models from Chopin
Model Number1
Profileg.54.1.1 - 2.10.230.10
Click for model details
zscore15.27
Residue begin177
Residue end237
Model Number2
Profileb.4.1.1, g.54.1.1 - 2.10.230.10, 2.60.260.20
Click for model details
zscore13.73
Residue begin1
Residue end56
Model Number3
Profilea.2.3.1 - 1.10.287.110
Click for model details
zscore9.49
Residue begin10
Residue end72
Model Number4
Profileb.4.1.1
Click for model details
zscore4.87
Residue begin235
Residue end290
Model Number5
Profileb.4.1.1
Click for model details
zscore4.87
Residue begin295
Residue end350
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0352Gene nameConfidence Score
Rv0350dnaK0.999
Rv0351grpE0.989
Rv0353hspR0.974
Rv2374chrcA0.937
Rv2374chrcA0.937
Rv2299chtpG0.936
Rv2299chtpG0.936
Rv2373cdnaJ20.934
Rv2373cdnaJ20.934
Rv2373cdnaJ20.934
Rv0384cclpB0.929
Rv0384cclpB0.929
Rv0384cclpB0.929
Rv0384cclpB0.929
Potential ligand/drug binding sites
Protein ModelPocket NumberDrug Binding Site PMIN ScorePvalue PMINPMAX ScorePvalue PMAX
Rv0352.122pgf_ADN_A_501PDBCREDO0.5350.2650.5350.006
Rv0352.312vn1_FK5_A_501PDBCREDO0.5660.2220.5220.008
Rv0352.122pgr_DCF_A_501PDBCREDO0.5330.2680.5140.009
Rv0352.311fap_RAP_A_108PDBCREDO0.5200.2880.5060.010
Rv0352.122ya7_ZMR_D_1776PDBCREDO0.5440.2520.5060.010
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions