Rv0353

Tuberculist information
Gene namehspR
Protein functionProbable heat shock protein transcriptional repressor HspR (MerR family)
Functional category(tuberculist)virulence,detoxification and adaptaion
Gene location(kb)423.639
Molecular mass(da)14126.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 126
	  		  	1    MAKNPKDGESRTFLISVAAELAGMHAQTLRTYDRLGLVSPRRTSGGGRRYSLHDVELLRQ   60
			  	61   VQHLSQDEGVNLAGIKRIIELTSQVEALQSRLQEMAEELAVLRANQRREVAVVPKSTALV  120
			  	121  VWKPRR

Known structures in the PDB
No Known structures
1 13 25 37 49 61 73 85 97 109 121 Range: 13 to 82  |  Coverage: 54% MerR_1 Range: 11 to 121  |  Coverage: 87% 1 Range: 10 to 81  |  Coverage: 56% 1 Range: 10 to 126  |  Coverage: 92% 2
Number of amino acids : 126
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
MerR_1PF1341113-82
Mtb Structural Proteome models
Model Number1
Model nameRv0353
Template1R8D    APDBCREDO
Template coverage1_109
Template Identity(%)24.8
Model coverage(%)87.3
Normalized DOPE score-0.03

Structure Models from Chopin
Model Number1
Profile1.10.1660.10
Click for model details
zscore14.04
Residue begin10
Residue end81
Model Number2
Profilea.6.1.3 - 1.10.1660.10
Click for model details
zscore14.01
Residue begin10
Residue end126
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0353Gene nameConfidence Score
Rv0384cclpB0.992
Rv0384cclpB0.992
Rv0384cclpB0.992
Rv0384cclpB0.992
Rv0350dnaK0.988
Rv0352dnaJ10.974
Rv0352dnaJ10.974
Rv0352dnaJ10.974
Rv0351grpE0.962
Rv3596cclpC10.945
Rv3596cclpC10.945
Rv3596cclpC10.945
Rv3596cclpC10.945
Rv3596cclpC10.945
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions