Rv0351

Tuberculist information
Gene namegrpE
Protein functionProbable GrpE protein (HSP-70 cofactor)
Functional category(tuberculist)virulence,detoxification and adaptaion
Gene location(kb)421.709
Molecular mass(da)24500.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 235
	  		  	1    VTDGNQKPDGNSGEQVTVTDKRRIDPETGEVRHVPPGDMPGGTAAADAAHTEDKVAELTA   60
			  	61   DLQRVQADFANYRKRALRDQQAAADRAKASVVSQLLGVLDDLERARKHGDLESGPLKSVA  120
			  	121  DKLDSALTGLGLVAFGAEGEDFDPVLHEAVQHEGDGGQGSKPVIGTVMRQGYQLGEQVLR  180
			  	181  HALVGVVDTVVVDAAELESVDDGTAVADTAENDQADQGNSADTSGEQAESEPSGS

Known structures in the PDB
No Known structures
1 24 47 70 93 116 139 162 185 208 231 Range: 25 to 188  |  Coverage: 69% GrpE Range: 52 to 186  |  Coverage: 57% 1 Range: 34 to 191  |  Coverage: 66% 1 Range: 34 to 130  |  Coverage: 40% 2 Range: 132 to 189  |  Coverage: 24% 3
Number of amino acids : 235
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GrpEPF0102525-188
Mtb Structural Proteome models
Model Number1
Model nameRv0351
Template1DKG    APDBCREDO
Template coverage41_192
Template Identity(%)31.9
Model coverage(%)57.0
Normalized DOPE score0.147

Structure Models from Chopin
Model Number1
Profileb.73.1.1, h.1.9.1 - 2.30.22.10, 3.90.20.20
Click for model details
zscore25.06
Residue begin34
Residue end191
Model Number2
Profile3.90.20.20
Click for model details
zscore18.83
Residue begin34
Residue end130
Model Number3
Profileb.73.1.1
Click for model details
zscore17.56
Residue begin132
Residue end189
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0351Gene nameConfidence Score
Rv0350dnaK0.999
Rv2374chrcA0.992
Rv2374chrcA0.992
Rv0352dnaJ10.989
Rv0352dnaJ10.989
Rv0352dnaJ10.989
Rv0384cclpB0.984
Rv0384cclpB0.984
Rv0384cclpB0.984
Rv0384cclpB0.984
Rv0440groEL20.976
Rv3417cgroEL10.974
Rv2373cdnaJ20.969
Rv2373cdnaJ20.969
Rv2373cdnaJ20.969
Rv0353hspR0.962
Rv3596cclpC10.942
Rv3596cclpC10.942
Rv3596cclpC10.942
Rv3596cclpC10.942
Rv3596cclpC10.942
Rv2299chtpG0.941
Rv2299chtpG0.941
Rv2461cclpP10.932
Rv3418cgroES0.926
Rv2462ctig0.902
Rv2462ctig0.902
Rv2462ctig0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions