Rv2461c

Tuberculist information
Gene nameclpP1
Protein functionProbable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2763.17
Molecular mass(da)21675.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 200
	  		  	1    VSQVTDMRSNSQGLSLTDSVYERLLSERIIFLGSEVNDEIANRLCAQILLLAAEDASKDI   60
			  	61   SLYINSPGGSISAGMAIYDTMVLAPCDIATYAMGMAASMGEFLLAAGTKGKRYALPHARI  120
			  	121  LMHQPLGGVTGSAADIAIQAEQFAVIKKEMFRLNAEFTGQPIERIEADSDRDRWFTAAEA  180
			  	181  LEYGFVDHIITRAHVNGEAQ

Known structures in the PDB
PDB ID2C8T
Total residue count2884
Number of chains14
MethodX-RAY
Resolution3
PDB ID2CBY
Total residue count1456
Number of chains7
MethodX-RAY
Resolution2.6
PDB ID2CE3
Total residue count2800
Number of chains14
MethodX-RAY
Resolution2.6
1 21 41 61 81 101 121 141 161 181 201 Range: 11 to 193  |  Coverage: 91% CLP_protease Range: 15 to 193  |  Coverage: 89% 1 Range: 15 to 193  |  Coverage: 89% 2 Range: 1 to 199  |  Coverage: 99% 1
Number of amino acids : 200
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
CLP_proteasePF0057411-193
Mtb Structural Proteome models
Model Number1
Model nameRv2461c_2cby_A
Template2CBY    APDBCREDO
Template coverage15_193
Template Identity(%)100.0
Model coverage(%)88.6
Normalized DOPE score-1.743

Model Number2
Model nameRv2461c
Template2CBY    APDBCREDO
Template coverage15_193
Template Identity(%)98.8
Model coverage(%)88.6
Normalized DOPE score-1.105

Structure Models from Chopin
Model Number1
Profilec.14.1.1 - 3.90.226.10
Click for model details
zscore40.91
Residue begin1
Residue end199
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2461cGene nameConfidence Score
Rv2457cclpX0.999
Rv2457cclpX0.999
Rv2457cclpX0.999
Rv2462ctig0.992
Rv2462ctig0.992
Rv2462ctig0.992
Rv3596cclpC10.983
Rv3596cclpC10.983
Rv3596cclpC10.983
Rv3596cclpC10.983
Rv3596cclpC10.983
Rv0384cclpB0.976
Rv0384cclpB0.976
Rv0384cclpB0.976
Rv0384cclpB0.976
Rv2374chrcA0.974
Rv2374chrcA0.974
Rv0350dnaK0.97
Rv3610cftsH0.968
Rv3610cftsH0.968
Rv3610cftsH0.968
Rv3417cgroEL10.961
Rv0440groEL20.941
Rv0351grpE0.932
Rv1223htrA0.931
Rv1223htrA0.931
Rv2460cclpP20.916
Rv0667rpoB0.907
Rv0667rpoB0.907
Rv0667rpoB0.907
Rv0667rpoB0.907
Rv0667rpoB0.907
Rv0667rpoB0.907
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions