Rv2460c

Tuberculist information
Gene nameclpP2
Protein functionProbable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2762.53
Molecular mass(da)23507.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 214
	  		  	1    VNSQNSQIQPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMAQL   60
			  	61   LVLESLDPDRDITMYINSPGGGFTSLMAIYDTMQYVRADIQTVCLGQAASAAAVLLAAGT  120
			  	121  PGKRMALPNARVLIHQPSLSGVIQGQFSDLEIQAAEIERMRTLMETTLARHTGKDAGVIR  180
			  	181  KDTDRDKILTAEEAKDYGIIDTVLEYRKLSAQTA

Known structures in the PDB
No Known structures
1 22 43 64 85 106 127 148 169 190 211 Range: 25 to 207  |  Coverage: 85% CLP_protease Range: 15 to 208  |  Coverage: 90% 1 Range: 9 to 213  |  Coverage: 95% 1
Number of amino acids : 214
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
CLP_proteasePF0057425-207
Mtb Structural Proteome models
Model Number1
Model nameRv2460c
Template2FZS    APDBCREDO
Template coverage2_193
Template Identity(%)50.0
Model coverage(%)90.2
Normalized DOPE score-0.853

Structure Models from Chopin
Model Number1
Profilec.14.1.1 - 3.90.226.10
Click for model details
zscore34.98
Residue begin9
Residue end213
Binding pockets
STRING
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Protein interacting with Rv2460cGene nameConfidence Score
Rv2457cclpX0.999
Rv2457cclpX0.999
Rv2457cclpX0.999
Rv2462ctig0.98
Rv2462ctig0.98
Rv2462ctig0.98
Rv3596cclpC10.979
Rv3596cclpC10.979
Rv3596cclpC10.979
Rv3596cclpC10.979
Rv3596cclpC10.979
Rv2461cclpP10.916
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions