Rv3596c

Tuberculist information
Gene nameclpC1
Protein functionProbable ATP-dependent protease ATP-binding subunit ClpC1
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)4038.16
Molecular mass(da)93552.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 848
	  		  	1    MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKSLESLGISLEGVR   60
			  	61   SQVEEIIGQGQQAPSGHIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVA  120
			  	121  AQVLVKLGAELTRVRQQVIQLLSGYQGKEAAEAGTGGRGGESGSPSTSLVLDQFGRNLTA  180
			  	181  AAMEGKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVHGEVPE  240
			  	241  TLKDKQLYTLDLGSLVAGSRYRGDFEERLKKVLKEINTRGDIILFIDELHTLVGAGAAEG  300
			  	301  AIDAASILKPKLARGELQTIGATTLDEYRKYIEKDAALERRFQPVQVGEPTVEHTIEILK  360
			  	361  GLRDRYEAHHRVSITDAAMVAAATLADRYINDRFLPDKAIDLIDEAGARMRIRRMTAPPD  420
			  	421  LREFDEKIAEARREKESAIDAQDFEKAASLRDREKTLVAQRAEREKQWRSGDLDVVAEVD  480
			  	481  DEQIAEVLGNWTGIPVFKLTEAETTRLLRMEEELHKRIIGQEDAVKAVSKAIRRTRAGLK  540
			  	541  DPKRPSGSFIFAGPSGVGKTELSKALANFLFGDDDALIQIDMGEFHDRFTASRLFGAPPG  600
			  	601  YVGYEEGGQLTEKVRRKPFSVVLFDEIEKAHQEIYNSLLQVLEDGRLTDGQGRTVDFKNT  660
			  	661  VLIFTSNLGTSDISKPVGLGFSKGGGENDYERMKQKVNDELKKHFRPEFLNRIDDIIVFH  720
			  	721  QLTREEIIRMVDLMISRVAGQLKSKDMALVLTDAAKALLAKRGFDPVLGARPLRRTIQRE  780
			  	781  IEDQLSEKILFEEVGPGQVVTVDVDNWDGEGPGEDAVFTFTGTRKPPAEPDLAKAGAHSA  840
			  	841  GGPEPAAR

Known structures in the PDB
PDB ID3WDB
Total residue count150
Number of chains1
MethodX-RAY
Resolution1.37
PDB ID3WDC
Total residue count160
Number of chains2
MethodX-RAY
Resolution1.18
PDB ID3WDD
Total residue count160
Number of chains2
MethodX-RAY
Resolution1.18
PDB ID3WDE
Total residue count160
Number of chains2
MethodX-RAY
Resolution1.44
1 85 169 253 337 421 505 589 673 757 841 Range: 16 to 68  |  Coverage: 6% Clp_N Range: 91 to 143  |  Coverage: 6% Clp_N Range: 212 to 347  |  Coverage: 15% AAA Range: 425 to 460  |  Coverage: 4% UVR Range: 544 to 716  |  Coverage: 20% AAA_2 Range: 722 to 802  |  Coverage: 9% ClpB_D2-small Range: 3 to 804  |  Coverage: 94% 1 Range: 1 to 53  |  Coverage: 6% 1 Range: 16 to 68  |  Coverage: 6% 2 Range: 91 to 143  |  Coverage: 6% 3 Range: 544 to 716  |  Coverage: 20% 4 Range: 517 to 597  |  Coverage: 9% 5 Range: 1 to 53  |  Coverage: 6% 6 Range: 212 to 347  |  Coverage: 15% 7
Number of amino acids : 848
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Clp_NPF0286116-68
Clp_NPF0286191-143
AAAPF00004212-347
UVRPF02151425-460
AAA_2PF07724544-716
ClpB_D2-smallPF10431722-802
Mtb Structural Proteome models
Model Number1
Model nameRv3596c
Template1QVR    APDBCREDO
Template coverage4_839
Template Identity(%)47.9
Model coverage(%)94.5
Normalized DOPE score0.017

Structure Models from Chopin
Model Number1
Profilea.174.1.1
Click for model details
zscore14.56
Residue begin1
Residue end53
Model Number2
Profilea.174.1.1
Click for model details
zscore14.56
Residue begin16
Residue end68
Model Number3
Profilea.174.1.1
Click for model details
zscore14.56
Residue begin91
Residue end143
Model Number4
Profilec.37.1.20
Click for model details
zscore11.86
Residue begin544
Residue end716
Model Number5
Profilec.37.1.20
Click for model details
zscore9.19
Residue begin517
Residue end597
Model Number6
Profilea.174.1.1, c.37.1.20 - 1.10.1780.10, 1.10.8.60, 3.40.50.300
Click for model details
zscore8.95
Residue begin1
Residue end53
Model Number7
Profilec.37.1.20 - 3.40.50.300
Click for model details
zscore5.66
Residue begin212
Residue end347
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3596cGene nameConfidence Score
Rv0350dnaK0.996
Rv2461cclpP10.983
Rv2460cclpP20.979
Rv2374chrcA0.978
Rv2374chrcA0.978
Rv2299chtpG0.961
Rv2299chtpG0.961
Rv3610cftsH0.952
Rv3610cftsH0.952
Rv3610cftsH0.952
Rv0353hspR0.945
Rv0351grpE0.942
Rv2031chspX0.908
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions