Rv2031c

Tuberculist information
Gene namehspX
Protein functionHeat shock protein HspX (alpha-crystallin homolog) (14 kDa antigen) (HSP16.3)
Functional category(tuberculist)virulence,detoxification and adaptaion
Gene location(kb)2278.5
Molecular mass(da)16227.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 144
	  		  	1    MATTLPVQRHPRSLFPEFSELFAAFPSFAGLRPTFDTRLMRLEDEMKEGRYEVRAELPGV   60
			  	61   DPDKDVDIMVRDGQLTIKAERTEQKDFDGRSEFAYGSFVRTVSLPVGADEDDIKATYDKG  120
			  	121  ILTVSVAVSEGKPTEKHIQIRSTN

Known structures in the PDB
No Known structures
1 15 29 43 57 71 85 99 113 127 141 Range: 44 to 141  |  Coverage: 67% HSP20 Range: 6 to 142  |  Coverage: 94% 1 Range: 29 to 144  |  Coverage: 79% 1
Number of amino acids : 144
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
HSP20PF0001144-141
Mtb Structural Proteome models
Model Number1
Model nameRv2031c
Template1GME    APDBCREDO
Template coverage12_151
Template Identity(%)29.9
Model coverage(%)94.4
Normalized DOPE score-0.073

Structure Models from Chopin
Model Number1
Profileb.15.1.1 - 2.60.40.790
Click for model details
zscore22.5
Residue begin29
Residue end144
Binding pockets
STRING
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Protein interacting with Rv2031cGene nameConfidence Score
Rv0350dnaK0.991
Rv3133cdevR0.968
Rv3133cdevR0.968
Rv0384cclpB0.958
Rv0384cclpB0.958
Rv0384cclpB0.958
Rv0384cclpB0.958
Rv0440groEL20.956
Rv2032acg0.926
Rv2028cRv2028c0.922
Rv2030cRv2030c0.911
Rv2030cRv2030c0.911
Rv3596cclpC10.908
Rv2029cpfkB0.908
Rv3596cclpC10.908
Rv3596cclpC10.908
Rv3596cclpC10.908
Rv3596cclpC10.908
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions