Rv1223

Tuberculist information
Gene namehtrA
Protein functionProbable serine protease HtrA (DEGP protein)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1365.88
Molecular mass(da)54157.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 528
	  		  	1    VDTRVDTDNAMPARFSAQIQNEDEVTSDQGNNGGPNGGGRLAPRPVFRPPVDPASRQAFG   60
			  	61   RPSGVQGSFVAERVRPQKYQDQSDFTPNDQLADPVLQEAFGRPFAGAESLQRHPIDAGAL  120
			  	121  AAEKDGAGPDEPDDPWRDPAAAAALGTPALAAPAPHGALAGSGKLGVRDVLFGGKVSYLA  180
			  	181  LGILVAIALVIGGIGGVIGRKTAEVVDAFTTSKVTLSTTGNAQEPAGRFTKVAAAVADSV  240
			  	241  VTIESVSDQEGMQGSGVIVDGRGYIVTNNHVISEAANNPSQFKTTVVFNDGKEVPANLVG  300
			  	301  RDPKTDLAVLKVDNVDNLTVARLGDSSKVRVGDEVLAVGAPLGLRSTVTQGIVSALHRPV  360
			  	361  PLSGEGSDTDTVIDAIQTDASINHGNSGGPLIDMDAQVIGINTAGKSLSDSASGLGFAIP  420
			  	421  VNEMKLVANSLIKDGKIVHPTLGISTRSVSNAIASGAQVANVKAGSPAQKGGILENDVIV  480
			  	481  KVGNRAVADSDEFVVAVRQLAIGQDAPIEVVREGRHVTLTVKPDPDST

Known structures in the PDB
No Known structures
1 53 105 157 209 261 313 365 417 469 521 Range: 254 to 401  |  Coverage: 27% Trypsin_2 Range: 440 to 522  |  Coverage: 15% PDZ_2 Range: 227 to 503  |  Coverage: 52% 1 Range: 219 to 528  |  Coverage: 58% 1 Range: 440 to 522  |  Coverage: 15% 2 Range: 254 to 401  |  Coverage: 27% 3 Range: 210 to 463  |  Coverage: 47% 4 Range: 17 to 499  |  Coverage: 91% 5
Number of amino acids : 528
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Trypsin_2PF13365254-401
PDZ_2PF13180440-522
Mtb Structural Proteome models
Model Number1
Model nameRv1223
Template1Y8T    APDBCREDO
Template coverage6_290
Template Identity(%)50.6
Model coverage(%)52.3
Normalized DOPE score-0.499

Structure Models from Chopin
Model Number1
Profileb.36.1.4, b.47.1.1 - 2.40.10.10
Click for model details
zscore46.36
Residue begin219
Residue end528
Model Number2
Profileb.36.1.4
Click for model details
zscore18.46
Residue begin440
Residue end522
Model Number3
Profileb.47.1.1
Click for model details
zscore14.72
Residue begin254
Residue end401
Model Number4
Profileb.47.1.3
Click for model details
zscore12.64
Residue begin210
Residue end463
Model Number5
Profileb.47.1.1
Click for model details
zscore9.32
Residue begin17
Residue end499
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1223Gene nameConfidence Score
Rv0350dnaK0.954
Rv2461cclpP10.931
Rv3227aroA0.914
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
pyruvic acidPubChem0.90688.0621
alpha-ketoglutaratePubChem0.9146.098
glutamatePubChem0.9147.129
hydroxyglutamic acidPubChem0.9163.129
C05947PubChem0.9163.129
2-keto-4-hydroxyglutaratePubChem0.9162.098
glyoxylatePubChem0.974.0355