Rv3417c

Tuberculist information
Gene namegroEL1
Protein function60 kDa chaperonin 1 GroEL1 (protein CPN60-1) (GroEL protein 1)
Functional category(tuberculist)virulence,detoxification and adaptaion
Gene location(kb)3835.27
Molecular mass(da)55877.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 539
	  		  	1    MSKLIEYDETARRAMEVGMDKLADTVRVTLGPRGRHVVLAKAFGGPTVTNDGVTVAREIE   60
			  	61   LEDPFEDLGAQLVKSVATKTNDVAGDGTTTATILAQALIKGGLRLVAAGVNPIALGVGIG  120
			  	121  KAADAVSEALLASATPVSGKTGIAQVATVSSRDEQIGDLVGEAMSKVGHDGVVSVEESST  180
			  	181  LGTELEFTEGIGFDKGFLSAYFVTDFDNQQAVLEDALILLHQDKISSLPDLLPLLEKVAG  240
			  	241  TGKPLLIVAEDVEGEALATLVVNAIRKTLKAVAVKGPYFGDRRKAFLEDLAVVTGGQVVN  300
			  	301  PDAGMVLREVGLEVLGSARRVVVSKDDTVIVDGGGTAEAVANRAKHLRAEIDKSDSDWDR  360
			  	361  EKLGERLAKLAGGVAVIKVGAATETALKERKESVEDAVAAAKAAVEEGIVPGGGASLIHQ  420
			  	421  ARKALTELRASLTGDEVLGVDVFSEALAAPLFWIAANAGLDGSVVVNKVSELPAGHGLNV  480
			  	481  NTLSYGDLAADGVIDPVKVTRSAVLNASSVARMVLTTETVVVDKPAKAEDHDHHHGHAH

Known structures in the PDB
PDB ID3M6C
Total residue count194
Number of chains1
MethodX-RAY
Resolution2.2
1 54 107 160 213 266 319 372 425 478 531 Range: 22 to 525  |  Coverage: 93% Cpn60_TCP1 Range: 2 to 527  |  Coverage: 97% 1 Range: 1 to 526  |  Coverage: 97% 1 Range: 273 to 527  |  Coverage: 47% 2 Range: 182 to 377  |  Coverage: 36% 3 Range: 135 to 227  |  Coverage: 17% 4
Number of amino acids : 539
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Cpn60_TCP1PF0011822-525
Mtb Structural Proteome models
Model Number1
Model nameRv3417c
Template1WE3    APDBCREDO
Template coverage3_529
Template Identity(%)54.9
Model coverage(%)97.4
Normalized DOPE score-0.55

Structure Models from Chopin
Model Number1
Profilea.129.1.1, c.8.5.1, d.56.1.1 - 1.10.560.10, 3.30.260.10, 3.50.7.10
Click for model details
zscore79.22
Residue begin1
Residue end526
Model Number2
Profile1.10.560.10
Click for model details
zscore41.81
Residue begin273
Residue end527
Model Number3
Profilec.8.5.1 - 3.50.7.10
Click for model details
zscore37.42
Residue begin182
Residue end377
Model Number4
Profile3.30.260.10
Click for model details
zscore16.89
Residue begin135
Residue end227
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3417cGene nameConfidence Score
Rv3418cgroES0.999
Rv0350dnaK0.996
Rv2374chrcA0.99
Rv2374chrcA0.99
Rv0685tuf0.982
Rv0685tuf0.982
Rv0685tuf0.982
Rv2299chtpG0.978
Rv2299chtpG0.978
Rv0351grpE0.974
Rv0667rpoB0.972
Rv2462ctig0.972
Rv0667rpoB0.972
Rv0667rpoB0.972
Rv0384cclpB0.972
Rv0667rpoB0.972
Rv0384cclpB0.972
Rv0667rpoB0.972
Rv0384cclpB0.972
Rv0667rpoB0.972
Rv2462ctig0.972
Rv0384cclpB0.972
Rv2462ctig0.972
Rv2461cclpP10.961
Rv1848ureA0.959
Rv3240csecA10.925
Rv3240csecA10.925
Rv3240csecA10.925
Rv2916cffh0.923
Rv2916cffh0.923
Rv2916cffh0.923
Rv1437pgk0.921
Rv2614cthrS0.919
Rv2614cthrS0.919
Rv2614cthrS0.919
Rv3846sodA0.914
Rv3846sodA0.914
Rv1617pykA0.911
Rv1617pykA0.911
Rv3610cftsH0.905
Rv3610cftsH0.905
Rv3610cftsH0.905
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
magnesiumPubChem0.7524.305
adenosine diphosphatePubChem0.704427.201