Rv2916c

Tuberculist information
Gene nameffh
Protein functionProbable signal recognition particle protein Ffh (fifty-four homolog) (SRP protein)
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)3224.71
Molecular mass(da)54969.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 525
	  		  	1    VFESLSDRLTAALQGLRGKGRLTDADIDATTREIRLALLEADVSLPVVRAFIHRIKERAR   60
			  	61   GAEVSSALNPAQQVVKIVNEELISILGGETRELAFAKTPPTVVMLAGLQGSGKTTLAGKL  120
			  	121  AARLRGQGHTPLLVACDLQRPAAVNQLQVVGERAGVPVFAPHPGASPESGPGDPVAVAAA  180
			  	181  GLAEARAKHFDVVIVDTAGRLGIDEELMAQAAAIRDAINPDEVLFVLDAMIGQDAVTTAA  240
			  	241  AFGEGVGFTGVALTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMASRI  300
			  	301  LGMGDVLSLIEQAEQVFDAQQAEEAAAKIGAGELTLEDFLEQMLAVRKMGPIGNLLGMLP  360
			  	361  GAAQMKDALAEVDDKQLDRVQAIIRGMTPQERADPKIINASRRLRIANGSGVTVSEVNQL  420
			  	421  VERFFEARKMMSSMLGGMGIPGIGRKSATRKSKGAKGKSGKKSKKGTRGPTPPKVKSPFG  480
			  	481  VPGMPGLAGLPGGLPDLSQMPKGLDELPPGLADFDLSKLKFPGKK

Known structures in the PDB
No Known structures
1 53 105 157 209 261 313 365 417 469 521 Range: 5 to 82  |  Coverage: 14% SRP54_N Range: 100 to 302  |  Coverage: 38% SRP54 Range: 333 to 431  |  Coverage: 18% SRP_SPB Range: 1 to 436  |  Coverage: 82% 1 Range: 5 to 435  |  Coverage: 81% 1 Range: 1 to 307  |  Coverage: 58% 2 Range: 333 to 431  |  Coverage: 18% 3 Range: 100 to 302  |  Coverage: 38% 4 Range: 5 to 82  |  Coverage: 14% 5
Number of amino acids : 525
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
SRP54_NPF028815-82
SRP54PF00448100-302
SRP_SPBPF02978333-431
Mtb Structural Proteome models
Model Number1
Model nameRv2916c
Template2FFH    APDBCREDO
Template coverage1_418
Template Identity(%)51.8
Model coverage(%)82.9
Normalized DOPE score-0.273

Structure Models from Chopin
Model Number1
Profilea.24.13.1, a.36.1.1, c.37.1.10
Click for model details
zscore76.61
Residue begin5
Residue end435
Model Number2
Profilea.24.13.1, c.37.1.10 - 1.20.120.140, 3.40.50.300
Click for model details
zscore55.44
Residue begin1
Residue end307
Model Number3
Profilea.36.1.1 - 1.10.260.30
Click for model details
zscore24.39
Residue begin333
Residue end431
Model Number4
Profilec.37.1.10 - 3.40.50.300
Click for model details
zscore15.98
Residue begin100
Residue end302
Model Number5
Profilea.24.13.1
Click for model details
zscore10.5
Residue begin5
Residue end82
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2916cGene nameConfidence Score
Rv0703rplW0.999
Rv2441crpmA0.999
Rv2442crplU0.999
Rv2906ctrmD0.989
Rv2904crplS0.986
Rv2909crpsP0.984
Rv2921cftsY0.983
Rv2921cftsY0.983
Rv0732secY0.978
Rv3443crplM0.972
Rv3459crpsK0.97
Rv2462ctig0.969
Rv2462ctig0.969
Rv2462ctig0.969
Rv0704rplB0.967
Rv0704rplB0.967
Rv3442crpsI0.966
Rv2587csecD0.962
Rv2586csecF0.962
Rv2586csecF0.962
Rv2587csecD0.962
Rv0702rplD0.96
Rv3456crplQ0.96
Rv2614cthrS0.956
Rv2614cthrS0.956
Rv2614cthrS0.956
Rv2907crimM0.956
Rv2907crimM0.956
Rv1298rpmE0.955
Rv0714rplN0.955
Rv2882cfrr0.954
Rv0716rplE0.953
Rv0716rplE0.953
Rv0640rplK0.951
Rv2890crpsB0.951
Rv2404clepA0.951
Rv2404clepA0.951
Rv2404clepA0.951
Rv2404clepA0.951
Rv0640rplK0.951
Rv1643rplT0.943
Rv2889ctsf0.937
Rv2889ctsf0.937
Rv2093ctatC0.934
Rv0056rplI0.932
Rv0056rplI0.932
Rv0720rplR0.932
Rv3240csecA10.928
Rv3240csecA10.928
Rv3240csecA10.928
Rv2925crnc0.927
Rv2925crnc0.927
Rv3646ctopA0.923
Rv3417cgroEL10.923
Rv0719rplF0.923
Rv2737crecA0.923
Rv3646ctopA0.923
Rv2737crecA0.923
Rv3646ctopA0.923
Rv1689tyrS0.922
Rv1689tyrS0.922
Rv2440cobg0.921
Rv2440cobg0.921
Rv3458crpsD0.921
Rv3458crpsD0.921
Rv2440cobg0.921
Rv0440groEL20.918
Rv2839cinfB0.915
Rv2839cinfB0.915
Rv2839cinfB0.915
Rv2839cinfB0.915
Rv0667rpoB0.914
Rv0667rpoB0.914
Rv0667rpoB0.914
Rv0667rpoB0.914
Rv2448cvalS0.914
Rv0667rpoB0.914
Rv2448cvalS0.914
Rv0667rpoB0.914
Rv2448cvalS0.914
Rv1641infC0.913
Rv1641infC0.913
Rv3457crpoA0.912
Rv0708rplP0.912
Rv3457crpoA0.912
Rv3457crpoA0.912
Rv0723rplO0.908
Rv0715rplX0.907
Rv0350dnaK0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions