Rv2889c

Tuberculist information
Gene nametsf
Protein functionProbable elongation factor Tsf (EF-ts)
Functional category(tuberculist)information pathways
Gene location(kb)3198.29
Molecular mass(da)28754.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 271
	  		  	1    MANFTAADVKRLRELTGAGMLACKNALAETDGDFDKAVEALRIKGAKDVGKRAERATAEG   60
			  	61   LVAAKDGALIELNCETDFVAKNAEFQTLADQVVAAAAAAKPADVDALKGASIGDKTVEQA  120
			  	121  IAELSAKIGEKLELRRVAIFDGTVEAYLHRRSADLPPAVGVLVEYRGDDAAAAHAVALQI  180
			  	181  AALRARYLSRDDVPEDIVASERRIAEETARAEGKPEQALPKIVEGRLNGFFKDAVLLEQA  240
			  	241  SVSDNKKTVKALLDVAGVTVTRFVRFEVGQA

Known structures in the PDB
No Known structures
1 28 55 82 109 136 163 190 217 244 271 Range: 4 to 41  |  Coverage: 13% UBA Range: 57 to 270  |  Coverage: 78% EF_TS Range: 2 to 270  |  Coverage: 98% 1 Range: 4 to 270  |  Coverage: 98% 1 Range: 135 to 271  |  Coverage: 50% 2 Range: 56 to 146  |  Coverage: 33% 3 Range: 1 to 58  |  Coverage: 21% 4 Range: 189 to 236  |  Coverage: 17% 5
Number of amino acids : 271
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
UBAPF006274-41
EF_TSPF0088957-270
Mtb Structural Proteome models
Model Number1
Model nameRv2889c
Template1EFU    BPDBCREDO
Template coverage1_262
Template Identity(%)41.2
Model coverage(%)98.9
Normalized DOPE score-0.029

Structure Models from Chopin
Model Number1
Profilea.5.2.2, d.43.1.1 - 1.10.286.20, 1.10.8.10, 3.30.479.20
Click for model details
zscore35.01
Residue begin4
Residue end270
Model Number2
Profiled.43.1.1
Click for model details
zscore18.83
Residue begin135
Residue end271
Model Number3
Profile3.30.479.20
Click for model details
zscore18.12
Residue begin56
Residue end146
Model Number4
Profilea.5.2.2
Click for model details
zscore14.8
Residue begin1
Residue end58
Model Number5
Profile1.10.286.20
Click for model details
zscore13.16
Residue begin189
Residue end236
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2889cGene nameConfidence Score
Rv2890crpsB0.999
Rv2882cfrr0.997
Rv2883cpyrH0.997
Rv0641rplA0.996
Rv3442crpsI0.995
Rv3443crplM0.995
Rv0684fusA10.992
Rv0704rplB0.992
Rv0684fusA10.992
Rv0684fusA10.992
Rv0684fusA10.992
Rv0684fusA10.992
Rv0704rplB0.992
Rv0701rplC0.989
Rv0702rplD0.988
Rv0719rplF0.987
Rv0685tuf0.986
Rv0682rpsL0.986
Rv0685tuf0.986
Rv0685tuf0.986
Rv0640rplK0.985
Rv0700rpsJ0.985
Rv0640rplK0.985
Rv0708rplP0.984
Rv0705rpsS0.983
Rv0716rplE0.983
Rv0716rplE0.983
Rv0056rplI0.983
Rv0056rplI0.983
Rv0707rpsC0.982
Rv0707rpsC0.982
Rv0721rpsE0.981
Rv0721rpsE0.981
Rv0714rplN0.98
Rv3460crpsM0.98
Rv1643rplT0.979
Rv0652rplL0.978
Rv2839cinfB0.975
Rv2839cinfB0.975
Rv2839cinfB0.975
Rv2839cinfB0.975
Rv2785crpsO0.974
Rv0703rplW0.972
Rv3457crpoA0.971
Rv3457crpoA0.971
Rv3457crpoA0.971
Rv0683rpsG0.971
Rv3458crpsD0.97
Rv3458crpsD0.97
Rv0718rpsH0.967
Rv2904crplS0.967
Rv1641infC0.966
Rv1641infC0.966
Rv0053rpsF0.964
Rv3459crpsK0.964
Rv0710rpsQ0.963
Rv1308atpA0.962
Rv0706rplV0.962
Rv1308atpA0.962
Rv1308atpA0.962
Rv1630rpsA0.962
Rv1023eno0.962
Rv1023eno0.962
Rv2462ctig0.961
Rv2462ctig0.961
Rv2462ctig0.961
Rv0720rplR0.96
Rv3456crplQ0.952
Rv0120cfusA20.951
Rv0120cfusA20.951
Rv0120cfusA20.951
Rv0120cfusA20.951
Rv0651rplJ0.951
Rv0120cfusA20.951
Rv0667rpoB0.95
Rv0667rpoB0.95
Rv0667rpoB0.95
Rv0667rpoB0.95
Rv1699pyrG0.95
Rv0732secY0.95
Rv0667rpoB0.95
Rv1699pyrG0.95
Rv0667rpoB0.95
Rv2442crplU0.949
Rv2906ctrmD0.949
Rv0639nusG0.948
Rv0639nusG0.948
Rv0723rplO0.945
Rv0350dnaK0.939
Rv2783cgpsI0.937
Rv2783cgpsI0.937
Rv2916cffh0.937
Rv2783cgpsI0.937
Rv2916cffh0.937
Rv2783cgpsI0.937
Rv2916cffh0.937
Rv2783cgpsI0.937
Rv2534cefp0.935
Rv2534cefp0.935
Rv2534cefp0.935
Rv2841cnusA0.933
Rv2841cnusA0.933
Rv1310atpD0.929
Rv1310atpD0.929
Rv1310atpD0.929
Rv1689tyrS0.928
Rv1689tyrS0.928
Rv2992cgltS0.927
Rv0733adk0.927
Rv0715rplX0.926
Rv2441crpmA0.921
Rv2412rpsT0.919
Rv3462cinfA0.918
Rv2909crpsP0.916
Rv0041leuS0.915
Rv0041leuS0.915
Rv1406fmt0.915
Rv0041leuS0.915
Rv1406fmt0.915
Rv2861cmapB0.914
Rv1014cpth0.913
Rv0668rpoC0.911
Rv0668rpoC0.911
Rv0668rpoC0.911
Rv0668rpoC0.911
Rv0668rpoC0.911
Rv1015crplY0.91
Rv1015crplY0.91
Rv1298rpmE0.909
Rv2907crimM0.904
Rv2907crimM0.904
Rv2921cftsY0.903
Rv2921cftsY0.903
Rv1017cprsA0.902
Rv1017cprsA0.902
Rv3646ctopA0.901
Rv3646ctopA0.901
Rv1438tpi0.901
Rv3646ctopA0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions