Rv1014c

Tuberculist information
Gene namepth
Protein functionProbable peptidyl-tRNA hydrolase Pth
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1133.33
Molecular mass(da)20455.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 191
	  		  	1    MAEPLLVVGLGNPGANYARTRHNLGFVVADLLAARLGAKFKAHKRSGAEVATGRSAGRSL   60
			  	61   VLAKPRCYMNESGRQIGPLAKFYSVAPANIIVIHDDLDLEFGRIRLKIGGGEGGHNGLRS  120
			  	121  VVAALGTKDFQRVRIGIGRPPGRKDPAAFVLENFTPAERAEVPTICEQAADATELLIEQG  180
			  	181  MEPAQNRVHAW

Known structures in the PDB
PDB ID2JRC
Total residue count204
Number of chains1
MethodNMR
ResolutionN/A
PDB ID2Z2I
Total residue count191
Number of chains1
MethodX-RAY
Resolution1.98
PDB ID2Z2J
Total residue count382
Number of chains2
MethodX-RAY
Resolution2.35
PDB ID2Z2K
Total residue count191
Number of chains1
MethodX-RAY
Resolution2.5
PDB ID3TCK
Total residue count191
Number of chains1
MethodX-RAY
Resolution2.3
PDB ID3TCN
Total residue count382
Number of chains2
MethodX-RAY
Resolution2.3
PDB ID3TD2
Total residue count191
Number of chains1
MethodX-RAY
Resolution2.5
PDB ID3TD6
Total residue count191
Number of chains1
MethodX-RAY
Resolution3.2
1 20 39 58 77 96 115 134 153 172 191 Range: 6 to 189  |  Coverage: 95% Pept_tRNA_hydro Range: 1 to 179  |  Coverage: 93% 1 Range: 3 to 180  |  Coverage: 92% 2 Range: 1 to 191  |  Coverage: 99% 1
Number of amino acids : 191
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Pept_tRNA_hydroPF011956-189
Mtb Structural Proteome models
Model Number1
Model nameRv1014c_2z2i_A
Template2Z2I    APDBCREDO
Template coverage1_179
Template Identity(%)100.0
Model coverage(%)93.2
Normalized DOPE score-1.858

Model Number2
Model nameRv1014c
Template1RYB    APDBCREDO
Template coverage2_179
Template Identity(%)43.3
Model coverage(%)92.7
Normalized DOPE score-1.38

Structure Models from Chopin
Model Number1
Profilec.56.3.1 - 3.40.50.1470
Click for model details
zscore49.35
Residue begin1
Residue end191
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1014cGene nameConfidence Score
Rv1015crplY0.988
Rv1015crplY0.988
Rv1112Rv11120.986
Rv1112Rv11120.986
Rv1017cprsA0.975
Rv1017cprsA0.975
Rv0684fusA10.97
Rv0684fusA10.97
Rv0684fusA10.97
Rv0684fusA10.97
Rv0684fusA10.97
Rv2882cfrr0.943
Rv3834cserS0.922
Rv3834cserS0.922
Rv3100csmpB0.921
Rv2839cinfB0.916
Rv2839cinfB0.916
Rv2839cinfB0.916
Rv2839cinfB0.916
Rv2889ctsf0.913
Rv2889ctsf0.913
Rv2555calaS0.907
Rv2555calaS0.907
Rv2555calaS0.907
Rv1023eno0.902
Rv1023eno0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
chloridePubChem0.92135.453
polyethylene glycolPubChem0.70962.0678