Rv2839c

Tuberculist information
Gene nameinfB
Protein functionProbable translation initiation factor if-2 InfB
Functional category(tuberculist)information pathways
Gene location(kb)3145.17
Molecular mass(da)94008.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 900
	  		  	1    VAAGKARVHELAKELGVTSKEVLARLSEQGEFVKSASSTVEAPVARRLRESFGGSKPAPA   60
			  	61   KGTAKSPGKGPDKSLDKALDAAIDMAAGNGKATAAPAKAADSGGAAIVSPTTPAAPEPPT  120
			  	121  AVPPSPQAPHPGMAPGARPGPVPKPGIRTPRVGNNPFSSAQPADRPIPRPPAPRPGTARP  180
			  	181  GVPRPGASPGSMPPRPGGAVGGARPPRPGAPRPGGRPGAPGAGRSDAGGGNYRGGGVGAA  240
			  	241  PGTGFRGRPGGGGGGRPGQRGGAAGAFGRPGGAPRRGRKSKRQKRQEYDSMQAPVVGGVR  300
			  	301  LPHGNGETIRLARGASLSDFADKIDANPAALVQALFNLGEMVTATQSVGDETLELLGSEM  360
			  	361  NYNVQVVSPEDEDRELLESFDLSYGEDEGGEEDLQVRPPVVTVMGHVDHGKTRLLDTIRK  420
			  	421  ANVREAEAGGITQHIGAYQVAVDLDGSQRLITFIDTPGHEAFTAMRARGAKATDIAILVV  480
			  	481  AADDGVMPQTVEAINHAQAADVPIVVAVNKIDKEGADPAKIRGQLTEYGLVPEEFGGDTM  540
			  	541  FVDISAKQGTNIEALEEAVLLTADAALDLRANPDMEAQGVAIEAHLDRGRGPVATVLVQR  600
			  	601  GTLRVGDSVVAGDAYGRVRRMVDEHGEDVEVALPSRPVQVIGFTSVPGAGDNFLVVDEDR  660
			  	661  IARQIADRRSARKRNALAARSRKRISLEDLDSALKETSQLNLILKGDNAGTVEALEEALM  720
			  	721  GIQVDDEVVLRVIDRGVGGITETNVNLASASDAVIIGFNVRAEGKATELASREGVEIRYY  780
			  	781  SVIYQAIDEIEQALRGLLKPIYEENQLGRAEIRALFRSSKVGLIAGCLVTSGVMRRNAKA  840
			  	841  RLLRDNIVVAENLSIASLRREKDDVTEVRDGFECGLTLGYADIKEGDVIESYELVQKERA  900

Known structures in the PDB
No Known structures
1 91 181 271 361 451 541 631 721 811 901 Range: 3 to 55  |  Coverage: 5% IF2_N Range: 313 to 363  |  Coverage: 5% IF2_N Range: 397 to 565  |  Coverage: 18% GTP_EFTU Range: 591 to 654  |  Coverage: 7% GTP_EFTU_D2 Range: 685 to 792  |  Coverage: 11% IF-2 Range: 217 to 619  |  Coverage: 44% 1 Range: 394 to 899  |  Coverage: 56% 2 Range: 685 to 792  |  Coverage: 11% 1 Range: 397 to 565  |  Coverage: 18% 2
Number of amino acids : 900
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
IF2_NPF047603-55
IF2_NPF04760313-363
GTP_EFTUPF00009397-565
GTP_EFTU_D2PF03144591-654
IF-2PF11987685-792
Mtb Structural Proteome models
Model Number1
Model nameRv2839c.1
Template1MKY    APDBCREDO
Template coverage2_408
Template Identity(%)14.6
Model coverage(%)44.7
Normalized DOPE score0.53

Model Number2
Model nameRv2839c
Template1G7S    APDBCREDO
Template coverage1_561
Template Identity(%)31.4
Model coverage(%)56.1
Normalized DOPE score0.845

Structure Models from Chopin
Model Number1
Profilec.20.1.1
Click for model details
zscore16.33
Residue begin685
Residue end792
Model Number2
Profilec.37.1.8 - 3.40.50.300
Click for model details
zscore12.93
Residue begin397
Residue end565
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2839cGene nameConfidence Score
Rv2838crbfA0.998
Rv2783cgpsI0.995
Rv2783cgpsI0.995
Rv2783cgpsI0.995
Rv2783cgpsI0.995
Rv2783cgpsI0.995
Rv2841cnusA0.994
Rv2841cnusA0.994
Rv2793ctruB0.988
Rv2793ctruB0.988
Rv2785crpsO0.986
Rv2580chisS0.979
Rv2580chisS0.979
Rv0041leuS0.978
Rv0041leuS0.978
Rv0041leuS0.978
Rv1112Rv11120.977
Rv1112Rv11120.977
Rv2889ctsf0.975
Rv2889ctsf0.975
Rv0668rpoC0.974
Rv0668rpoC0.974
Rv0668rpoC0.974
Rv0668rpoC0.974
Rv0668rpoC0.974
Rv2837cRv2837c0.971
Rv0667rpoB0.971
Rv0667rpoB0.971
Rv0667rpoB0.971
Rv0667rpoB0.971
Rv0667rpoB0.971
Rv0667rpoB0.971
Rv2837cRv2837c0.971
Rv0704rplB0.97
Rv0704rplB0.97
Rv0641rplA0.969
Rv1299prfA0.967
Rv1299prfA0.967
Rv0732secY0.967
Rv2890crpsB0.966
Rv2882cfrr0.966
Rv0718rpsH0.964
Rv0721rpsE0.964
Rv0721rpsE0.964
Rv1649pheS0.961
Rv1649pheS0.961
Rv2572caspS0.96
Rv2572caspS0.96
Rv2572caspS0.96
Rv0702rplD0.957
Rv2448cvalS0.955
Rv2448cvalS0.955
Rv3442crpsI0.955
Rv2448cvalS0.955
Rv0720rplR0.954
Rv0639nusG0.953
Rv0639nusG0.953
Rv0719rplF0.952
Rv2845cproS0.951
Rv2845cproS0.951
Rv2845cproS0.951
Rv0716rplE0.95
Rv0716rplE0.95
Rv0640rplK0.948
Rv0640rplK0.948
Rv2883cpyrH0.947
Rv0705rpsS0.947
Rv3460crpsM0.947
Rv0701rplC0.946
Rv3457crpoA0.943
Rv3457crpoA0.943
Rv3457crpoA0.943
Rv0707rpsC0.941
Rv0707rpsC0.941
Rv1630rpsA0.941
Rv1406fmt0.94
Rv1406fmt0.94
Rv0703rplW0.938
Rv2842cRv2842c0.937
Rv2440cobg0.936
Rv2440cobg0.936
Rv2440cobg0.936
Rv2462ctig0.935
Rv2462ctig0.935
Rv2462ctig0.935
Rv0652rplL0.934
Rv2840cRv2840c0.933
Rv3443crplM0.932
Rv3458crpsD0.93
Rv3458crpsD0.93
Rv0700rpsJ0.93
Rv3459crpsK0.929
Rv3834cserS0.928
Rv3834cserS0.928
Rv2343cdnaG0.927
Rv2343cdnaG0.927
Rv2343cdnaG0.927
Rv2343cdnaG0.927
Rv2343cdnaG0.927
Rv0056rplI0.923
Rv0056rplI0.923
Rv3721cdnaZX0.922
Rv1007cmetS0.922
Rv3721cdnaZX0.922
Rv0706rplV0.921
Rv1547dnaE10.92
Rv1547dnaE10.92
Rv1547dnaE10.92
Rv1547dnaE10.92
Rv3336ctrpS0.919
Rv1689tyrS0.919
Rv1689tyrS0.919
Rv0651rplJ0.919
Rv2925crnc0.917
Rv2925crnc0.917
Rv2992cgltS0.916
Rv1014cpth0.916
Rv1437pgk0.916
Rv2916cffh0.915
Rv2916cffh0.915
Rv2916cffh0.915
Rv0708rplP0.912
Rv1292argS0.911
Rv1292argS0.911
Rv1292argS0.911
Rv0350dnaK0.909
Rv0710rpsQ0.906
Rv1641infC0.904
Rv1641infC0.904
Rv2906ctrmD0.902
Rv0714rplN0.901
Rv3456crplQ0.901
Potential ligand/drug binding sites
Protein ModelPocket NumberDrug Binding Site PMIN ScorePvalue PMINPMAX ScorePvalue PMAX
Rv2839c.132y7j_B49_B_1294PDBCREDO0.6470.1270.5980.002
Rv2839c.133g5d_1N1_B_1PDBCREDO0.5380.2600.5380.006
Rv2839c.133g5d_1N1_A_1PDBCREDO0.5360.2640.5360.006
Rv2839c.133qlg_1N1_B_601PDBCREDO0.5340.2670.5340.006
Rv2839c.132zva_1N1_A_513PDBCREDO0.5540.2390.5320.007
Rv2839c.133qlg_1N1_A_601PDBCREDO0.5320.2700.5320.007
Rv2839c.132pgf_ADN_A_501PDBCREDO0.5720.2150.5300.007
Rv2839c.131kij_NOV_B_444PDBCREDO0.5480.2460.5280.007
Rv2839c.132y7j_B49_D_1294PDBCREDO0.7030.0780.5250.007
Rv2839c.133kw2_ADN_A_300PDBCREDO0.5620.2280.5210.008
Rv2839c.133ti1_B49_A_299PDBCREDO0.5190.2890.5190.008
Rv2839c.131jzs_MRC_A_1301PDBCREDO0.5280.2760.5080.010
Rv2839c.131d4f_ADN_A_601PDBCREDO0.5230.2830.5030.010
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
fMetPubChem0.739177.221