Rv0639

Tuberculist information
Gene namenusG
Protein functionProbable transcription antitermination protein NusG
Functional category(tuberculist)information pathways
Gene location(kb)734.254
Molecular mass(da)25414.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 238
	  		  	1    VTTFDGDTSAGEAVDLTEANAFQDAAAPAEEVDPAAALKAELRSKPGDWYVVHSYAGYEN   60
			  	61   KVKANLETRVQNLDVGDYIFQVEVPTEEVTEIKNGQRKQVNRKVLPGYILVRMDLTDDSW  120
			  	121  AAVRNTPGVTGFVGATSRPSALALDDVVKFLLPRGSTRKAAKGAASTAAAAEAGGLERPV  180
			  	181  VEVDYEVGESVTVMDGPFATLPATISEVNAEQQKLKVLVSIFGRETPVELTFGQVSKI

Known structures in the PDB
PDB ID2MI6
Total residue count62
Number of chains1
MethodNMR
ResolutionN/A
1 24 47 70 93 116 139 162 185 208 231 Range: 47 to 145  |  Coverage: 41% NusG Range: 187 to 222  |  Coverage: 14% KOW Range: 41 to 238  |  Coverage: 82% 1 Range: 45 to 155  |  Coverage: 46% 1 Range: 1 to 237  |  Coverage: 99% 2 Range: 181 to 238  |  Coverage: 23% 3
Number of amino acids : 238
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NusGPF0235747-145
KOWPF00467187-222
Mtb Structural Proteome models
Model Number1
Model nameRv0639
Template1NPP    APDBCREDO
Template coverage5_248
Template Identity(%)33.8
Model coverage(%)82.8
Normalized DOPE score0.221

Structure Models from Chopin
Model Number1
Profile3.30.70.940
Click for model details
zscore27.33
Residue begin45
Residue end155
Model Number2
Profileb.114.1.1, b.34.5.4 - 2.30.30.30, 2.60.320.10, 3.30.70.940
Click for model details
zscore26.69
Residue begin1
Residue end237
Model Number3
Profileb.34.5.4 - 2.30.30.30
Click for model details
zscore19.85
Residue begin181
Residue end238
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0639Gene nameConfidence Score
Rv0667rpoB0.998
Rv0667rpoB0.998
Rv0667rpoB0.998
Rv0667rpoB0.998
Rv0667rpoB0.998
Rv0667rpoB0.998
Rv0700rpsJ0.997
Rv0641rplA0.996
Rv0640rplK0.996
Rv0640rplK0.996
Rv0668rpoC0.995
Rv0668rpoC0.995
Rv0668rpoC0.995
Rv0668rpoC0.995
Rv0668rpoC0.995
Rv3457crpoA0.994
Rv3457crpoA0.994
Rv3457crpoA0.994
Rv0718rpsH0.993
Rv1297rho0.992
Rv1297rho0.992
Rv1297rho0.992
Rv0652rplL0.992
Rv0708rplP0.991
Rv0732secY0.99
Rv2533cnusB0.988
Rv0683rpsG0.988
Rv0716rplE0.986
Rv0716rplE0.986
Rv0701rplC0.983
Rv0651rplJ0.983
Rv0714rplN0.982
Rv0682rpsL0.981
Rv0719rplF0.981
Rv0685tuf0.979
Rv0685tuf0.979
Rv0685tuf0.979
Rv0707rpsC0.978
Rv0707rpsC0.978
Rv3458crpsD0.977
Rv3458crpsD0.977
Rv0634BrpmG20.974
Rv0684fusA10.973
Rv0684fusA10.973
Rv0684fusA10.973
Rv0684fusA10.973
Rv0684fusA10.973
Rv3460crpsM0.972
Rv2462ctig0.97
Rv2462ctig0.97
Rv2462ctig0.97
Rv0702rplD0.969
Rv0703rplW0.969
Rv0705rpsS0.969
Rv0721rpsE0.968
Rv0721rpsE0.968
Rv0704rplB0.965
Rv0638secE10.965
Rv0704rplB0.965
Rv3459crpsK0.962
Rv0710rpsQ0.959
Rv0733adk0.959
Rv2904crplS0.954
Rv2839cinfB0.953
Rv2839cinfB0.953
Rv2839cinfB0.953
Rv2839cinfB0.953
Rv2889ctsf0.948
Rv2889ctsf0.948
Rv0723rplO0.946
Rv0715rplX0.944
Rv1080cgreA0.941
Rv1080cgreA0.941
Rv2783cgpsI0.939
Rv2783cgpsI0.939
Rv2783cgpsI0.939
Rv2783cgpsI0.939
Rv2783cgpsI0.939
Rv2909crpsP0.939
Rv2343cdnaG0.933
Rv2343cdnaG0.933
Rv0717rpsN10.933
Rv2343cdnaG0.933
Rv2343cdnaG0.933
Rv2343cdnaG0.933
Rv2841cnusA0.931
Rv2841cnusA0.931
Rv3456crplQ0.929
Rv2906ctrmD0.928
Rv3715crecR0.922
Rv3715crecR0.922
Rv3715crecR0.922
Rv2883cpyrH0.921
Rv2992cgltS0.915
Rv0720rplR0.915
Rv2890crpsB0.908
Rv0041leuS0.907
Rv0041leuS0.907
Rv0041leuS0.907
Rv1641infC0.907
Rv1641infC0.907
Rv1010ksgA0.906
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
bicyclomycinPubChem0.795302.281