Rv3460c

Tuberculist information
Gene namerpsM
Protein function30S ribosomal protein S13 RpsM
Functional category(tuberculist)information pathways
Gene location(kb)3879.7
Molecular mass(da)14350.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 124
	  		  	1    MARLVGVDLPRDKRMEVALTYIFGIGRTRSNEILAATGIDRDLRTRDLTEEQLIHLRDYI   60
			  	61   EANLKVEGDLRREVQADIRRKIEIGCYQGLRHRRGMPVRGQRTKTNARTRKGPKRTIAGK  120
			  	121  KKAR

Known structures in the PDB
No Known structures
1 13 25 37 49 61 73 85 97 109 121 Range: 3 to 109  |  Coverage: 85% Ribosomal_S13 Range: 2 to 124  |  Coverage: 98% 1 Range: 2 to 124  |  Coverage: 98% 1 Range: 73 to 124  |  Coverage: 41% 2
Number of amino acids : 124
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Ribosomal_S13PF004163-109
Mtb Structural Proteome models
Model Number1
Model nameRv3460c
Template1FJG    MPDBCREDO
Template coverage2_124
Template Identity(%)61.8
Model coverage(%)98.4
Normalized DOPE score-0.322

Structure Models from Chopin
Model Number1
Profilea.156.1.1
Click for model details
zscore23.08
Residue begin2
Residue end124
Model Number2
Profile4.10.910.10
Click for model details
zscore14.94
Residue begin73
Residue end124
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3460cGene nameConfidence Score
Rv0700rpsJ0.999
Rv0707rpsC0.999
Rv0721rpsE0.999
Rv0716rplE0.999
Rv0707rpsC0.999
Rv0721rpsE0.999
Rv0716rplE0.999
Rv3458crpsD0.999
Rv3458crpsD0.999
Rv3459crpsK0.999
Rv0701rplC0.998
Rv0682rpsL0.998
Rv3442crpsI0.998
Rv0683rpsG0.998
Rv0718rpsH0.998
Rv0710rpsQ0.998
Rv0719rplF0.997
Rv3457crpoA0.997
Rv2890crpsB0.997
Rv3457crpoA0.997
Rv0702rplD0.997
Rv3457crpoA0.997
Rv0705rpsS0.997
Rv3456crplQ0.997
Rv0714rplN0.996
Rv0640rplK0.996
Rv0685tuf0.996
Rv0708rplP0.996
Rv0704rplB0.996
Rv0685tuf0.996
Rv0704rplB0.996
Rv0685tuf0.996
Rv0640rplK0.996
Rv0641rplA0.995
Rv3443crplM0.995
Rv0717rpsN10.995
Rv0706rplV0.994
Rv0720rplR0.994
Rv0715rplX0.994
Rv0651rplJ0.994
Rv0723rplO0.994
Rv2056crpsN20.993
Rv3462cinfA0.992
Rv1641infC0.992
Rv1641infC0.992
Rv0652rplL0.992
Rv0667rpoB0.991
Rv0684fusA10.991
Rv0667rpoB0.991
Rv0684fusA10.991
Rv0667rpoB0.991
Rv0684fusA10.991
Rv0703rplW0.991
Rv0667rpoB0.991
Rv0667rpoB0.991
Rv0684fusA10.991
Rv0667rpoB0.991
Rv0684fusA10.991
Rv0732secY0.99
Rv0053rpsF0.988
Rv0722rpmD0.988
Rv0668rpoC0.987
Rv0668rpoC0.987
Rv0668rpoC0.987
Rv0668rpoC0.987
Rv0668rpoC0.987
Rv2785crpsO0.987
Rv2909crpsP0.985
Rv2904crplS0.983
Rv2889ctsf0.98
Rv2441crpmA0.98
Rv2889ctsf0.98
Rv3100csmpB0.979
Rv2906ctrmD0.977
Rv2882cfrr0.977
Rv1643rplT0.975
Rv3461crpmJ0.972
Rv0639nusG0.972
Rv0709rpmC0.972
Rv0639nusG0.972
Rv1023eno0.97
Rv1023eno0.97
Rv0733adk0.969
Rv2412rpsT0.968
Rv1298rpmE0.968
Rv0734mapA0.968
Rv2861cmapB0.964
Rv2442crplU0.961
Rv0055rpsR10.959
Rv3455ctruA0.953
Rv2839cinfB0.947
Rv2839cinfB0.947
Rv2839cinfB0.947
Rv2839cinfB0.947
Rv2534cefp0.944
Rv2534cefp0.944
Rv2534cefp0.944
Rv1297rho0.941
Rv1297rho0.941
Rv1297rho0.941
Rv0056rplI0.938
Rv0056rplI0.938
Rv2907crimM0.938
Rv2907crimM0.938
Rv2057crpmG10.92
Rv2992cgltS0.917
Rv0120cfusA20.905
Rv0120cfusA20.905
Rv0120cfusA20.905
Rv0120cfusA20.905
Rv0120cfusA20.905
Rv2783cgpsI0.902
Rv2783cgpsI0.902
Rv2783cgpsI0.902
Rv2783cgpsI0.902
Rv2783cgpsI0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB00560DrugBankTigecycline
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
spectinomycinPubChem0.881332.35
streptomycinPubChem0.819581.574
magnesiumPubChem0.78924.305
guanosine diphosphatePubChem0.789443.201
5-methylcytidylic acidPubChem0.71337.223
adenosine 3',5'-diphosphatePubChem0.71427.201
[3,4-dihydroxy-5-(6-imino-1-methyl-purin-9-yl)oxolan-2-yl]methoxyphosphonic AcidPubChem0.71361.248
pactamycinPubChem0.71558.623
adenosine monophosphatePubChem0.71347.221
C04639PubChem0.71326.197
polyuridylic acidPubChem0.71324.181
pseudouridine 5'-phosphatePubChem0.71324.181
CSIPubChem0.71172.185
kasugamycinPubChem0.71379.363
2,3-diaminopropionic acidPubChem0.71104.108
phenylalaninalPubChem0.71149.19
MYC-8003PubChem0.71796.943
7mgPubChem0.71379.263
UD29PubChem0.71340.247
kirromycinPubChem0.71796.943
[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl phosphatePubChem0.71338.208
2'-O-methylguanosine 5'-monophosphatePubChem0.71377.247
potassiumPubChem0.7139.0983
L-2,3-diaminopropionic acidPubChem0.71104.108
[5-(2-dimethylamino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic AcidPubChem0.71391.274
3'-phosphoadenosine 5'-phosphatePubChem0.71427.201
poly(2'-O-methylcytidylic acid)PubChem0.71337.223
pseudouridylic acidPubChem0.71324.181
L-beta-lysinePubChem0.71146.188
DB08185PubChem0.71463.446
zincPubChem0.7165.409
poly CPubChem0.71323.197
3'-amino-3'-deoxy AMPPubChem0.71346.236
2-mercaptoethanolPubChem0.7178.1334
CHEBI:603702PubChem0.71558.623
poly(2'-O-methyladenylic acid)PubChem0.71361.248
beta-lysinePubChem0.71146.188
methyl 4-[3-[3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]-4,6-dimethyl-9-oxoimidazo[1,2-a]purin-PubChem0.71588.462
fusidic acidPubChem0.71516.709
[(2R,3S,4R,5R)-5-[2-(dimethylamino)-6-oxo-3H-purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen PubChem0.71391.274
ara-TMPPubChem0.71338.208
guanylatePubChem0.71363.221
potassium hydridePubChem0.7140.1062
[3,4-dihydroxy-5-(2-methylamino-6-oxo-3H-purin-9-yl)oxolan-2-yl]methoxyphosphonic AcidPubChem0.71377.247
guanylyl-(alpha,beta)-methylene-diphosphonatePubChem0.71521.208
C07026PubChem0.71346.236