Rv0734

Tuberculist information
Gene namemapA
Protein functionMethionine aminopeptidase MapA (map) (peptidase M) (MetAP)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)826.67
Molecular mass(da)27276.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 266
	  		  	1    MRPLARLRGRRVVPQRSAGELDAMAAAGAVVAAALRAIRAAAAPGTSSLSLDEIAESVIR   60
			  	61   ESGATPSFLGYHGYPASICASINDRVVHGIPSTAEVLAPGDLVSIDCGAVLDGWHGDAAI  120
			  	121  TFGVGALSDADEALSEATRESLQAGIAAMVVGNRLTDVAHAIETGTRAAELRYGRSFGIV  180
			  	181  AGYGGHGIGRQMHMDPFLPNEGAPGRGPLLAAGSVLAIEPMLTLGTTKTVVLDDKWTVTT  240
			  	241  ADGSRAAHWEHTVAVTDDGPRILTLG

Known structures in the PDB
No Known structures
1 27 53 79 105 131 157 183 209 235 261 Range: 22 to 257  |  Coverage: 88% Peptidase_M24 Range: 12 to 264  |  Coverage: 94% 1 Range: 1 to 266  |  Coverage: 99% 1
Number of amino acids : 266
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Peptidase_M24PF0055722-257
Mtb Structural Proteome models
Model Number1
Model nameRv0734
Template1O0X    APDBCREDO
Template coverage6_252
Template Identity(%)40.9
Model coverage(%)94.4
Normalized DOPE score-0.472

Structure Models from Chopin
Model Number1
Profiled.127.1.1 - 3.90.230.10
Click for model details
zscore32.58
Residue begin1
Residue end266
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0734Gene nameConfidence Score
Rv0732secY0.998
Rv0733adk0.998
Rv0714rplN0.986
Rv0716rplE0.985
Rv3459crpsK0.985
Rv0716rplE0.985
Rv0708rplP0.984
Rv3456crplQ0.984
Rv0720rplR0.981
Rv0723rplO0.979
Rv0710rpsQ0.978
Rv0700rpsJ0.977
Rv0721rpsE0.977
Rv0702rplD0.977
Rv0721rpsE0.977
Rv0718rpsH0.976
Rv0715rplX0.976
Rv0703rplW0.976
Rv3457crpoA0.975
Rv3457crpoA0.975
Rv3457crpoA0.975
Rv0705rpsS0.975
Rv0719rplF0.975
Rv0701rplC0.975
Rv0704rplB0.973
Rv0704rplB0.973
Rv0707rpsC0.972
Rv0707rpsC0.972
Rv0717rpsN10.971
Rv0706rplV0.968
Rv3460crpsM0.968
Rv3458crpsD0.96
Rv3458crpsD0.96
Rv0684fusA10.946
Rv0684fusA10.946
Rv0684fusA10.946
Rv0684fusA10.946
Rv0684fusA10.946
Rv0709rpmC0.938
Rv3462cinfA0.934
Rv0668rpoC0.931
Rv0668rpoC0.931
Rv0668rpoC0.931
Rv0668rpoC0.931
Rv0668rpoC0.931
Rv0722rpmD0.903
Rv2056crpsN20.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
cobaltPubChem0.864117.866