Rv0705

Tuberculist information
Gene namerpsS
Protein function30S ribosomal protein S19 RpsS
Functional category(tuberculist)information pathways
Gene location(kb)803.411
Molecular mass(da)10803.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 93
	  		  	1    MPRSLKKGPFVDEHLLKKVDVQNEKNTKQVIKTWSRRSTIIPDFIGHTFAVHDGRKHVPV   60
			  	61   FVTESMVGHKLGEFAPTRTFKGHIKDDRKSKRR

Known structures in the PDB
No Known structures
1 10 19 28 37 46 55 64 73 82 91 Range: 3 to 83  |  Coverage: 86% Ribosomal_S19 Range: 2 to 85  |  Coverage: 89% 1 Range: 2 to 82  |  Coverage: 86% 1
Number of amino acids : 93
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Ribosomal_S19PF002033-83
Mtb Structural Proteome models
Model Number1
Model nameRv0705
Template1FJG    SPDBCREDO
Template coverage2_85
Template Identity(%)69.0
Model coverage(%)89.2
Normalized DOPE score-0.547

Structure Models from Chopin
Model Number1
Profiled.28.1.1 - 3.30.860.10
Click for model details
zscore21.25
Residue begin2
Residue end82
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0705Gene nameConfidence Score
Rv0721rpsE0.999
Rv0702rplD0.999
Rv0708rplP0.999
Rv0703rplW0.999
Rv0704rplB0.999
Rv0710rpsQ0.999
Rv0704rplB0.999
Rv0706rplV0.999
Rv3459crpsK0.999
Rv0700rpsJ0.999
Rv0707rpsC0.999
Rv0721rpsE0.999
Rv0707rpsC0.999
Rv0682rpsL0.998
Rv3442crpsI0.998
Rv0683rpsG0.998
Rv3458crpsD0.998
Rv0718rpsH0.998
Rv3458crpsD0.998
Rv2890crpsB0.997
Rv0717rpsN10.997
Rv0714rplN0.997
Rv3460crpsM0.997
Rv0701rplC0.997
Rv0716rplE0.996
Rv0709rpmC0.996
Rv0716rplE0.996
Rv3457crpoA0.995
Rv0651rplJ0.995
Rv2056crpsN20.995
Rv3457crpoA0.995
Rv0719rplF0.995
Rv0720rplR0.995
Rv0715rplX0.995
Rv3457crpoA0.995
Rv0641rplA0.995
Rv0652rplL0.993
Rv0640rplK0.993
Rv0640rplK0.993
Rv0668rpoC0.992
Rv0684fusA10.992
Rv0685tuf0.992
Rv0723rplO0.992
Rv0668rpoC0.992
Rv0685tuf0.992
Rv3443crplM0.992
Rv0684fusA10.992
Rv0668rpoC0.992
Rv0685tuf0.992
Rv0684fusA10.992
Rv0668rpoC0.992
Rv3456crplQ0.992
Rv0684fusA10.992
Rv0668rpoC0.992
Rv0684fusA10.992
Rv0722rpmD0.99
Rv0732secY0.99
Rv0667rpoB0.989
Rv0667rpoB0.989
Rv0667rpoB0.989
Rv0667rpoB0.989
Rv0667rpoB0.989
Rv0667rpoB0.989
Rv2785crpsO0.985
Rv0053rpsF0.985
Rv2889ctsf0.983
Rv1641infC0.983
Rv1641infC0.983
Rv2889ctsf0.983
Rv2882cfrr0.981
Rv2907crimM0.976
Rv2907crimM0.976
Rv0734mapA0.975
Rv2904crplS0.974
Rv0639nusG0.969
Rv0639nusG0.969
Rv0056rplI0.966
Rv0056rplI0.966
Rv2861cmapB0.963
Rv2412rpsT0.962
Rv3100csmpB0.96
Rv2441crpmA0.96
Rv2909crpsP0.959
Rv2906ctrmD0.955
Rv0733adk0.953
Rv2442crplU0.949
Rv2839cinfB0.947
Rv2839cinfB0.947
Rv2839cinfB0.947
Rv2839cinfB0.947
Rv1643rplT0.944
Rv0055rpsR10.941
Rv1308atpA0.936
Rv1308atpA0.936
Rv1308atpA0.936
Rv0120cfusA20.935
Rv0120cfusA20.935
Rv0120cfusA20.935
Rv0120cfusA20.935
Rv0120cfusA20.935
Rv1649pheS0.933
Rv1649pheS0.933
Rv3455ctruA0.925
Rv2534cefp0.907
Rv2534cefp0.907
Rv2534cefp0.907
Rv2057crpmG10.905
Rv2580chisS0.901
Rv2580chisS0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB00560DrugBankTigecycline
DB00759DrugBankTetracycline
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
spectinomycinPubChem0.789332.35
guanosine diphosphatePubChem0.789443.201
magnesiumPubChem0.78924.305
zincPubChem0.74165.409
CSIPubChem0.71172.185
kasugamycinPubChem0.71379.363
2,3-diaminopropionic acidPubChem0.71104.108
phenylalaninalPubChem0.71149.19
MYC-8003PubChem0.71796.943
7mgPubChem0.71379.263
UD29PubChem0.71340.247
kirromycinPubChem0.71796.943
[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl phosphatePubChem0.71338.208
2'-O-methylguanosine 5'-monophosphatePubChem0.71377.247
potassiumPubChem0.7139.0983
L-2,3-diaminopropionic acidPubChem0.71104.108
[5-(2-dimethylamino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic AcidPubChem0.71391.274
streptomycinPubChem0.71581.574
3'-phosphoadenosine 5'-phosphatePubChem0.71427.201
poly(2'-O-methylcytidylic acid)PubChem0.71337.223
pseudouridylic acidPubChem0.71324.181
L-beta-lysinePubChem0.71146.188
DB08185PubChem0.71463.446
poly CPubChem0.71323.197
3'-amino-3'-deoxy AMPPubChem0.71346.236
2-mercaptoethanolPubChem0.7178.1334
CHEBI:603702PubChem0.71558.623
poly(2'-O-methyladenylic acid)PubChem0.71361.248
beta-lysinePubChem0.71146.188
methyl 4-[3-[3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]-4,6-dimethyl-9-oxoimidazo[1,2-a]purin-PubChem0.71588.462
fusidic acidPubChem0.71516.709
[(2R,3S,4R,5R)-5-[2-(dimethylamino)-6-oxo-3H-purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen PubChem0.71391.274
ara-TMPPubChem0.71338.208
guanylatePubChem0.71363.221
potassium hydridePubChem0.7140.1062
[3,4-dihydroxy-5-(2-methylamino-6-oxo-3H-purin-9-yl)oxolan-2-yl]methoxyphosphonic AcidPubChem0.71377.247
guanylyl-(alpha,beta)-methylene-diphosphonatePubChem0.71521.208
C07026PubChem0.71346.236
5-methylcytidylic acidPubChem0.71337.223
adenosine 3',5'-diphosphatePubChem0.71427.201
[3,4-dihydroxy-5-(6-imino-1-methyl-purin-9-yl)oxolan-2-yl]methoxyphosphonic AcidPubChem0.71361.248
pactamycinPubChem0.71558.623
adenosine monophosphatePubChem0.71347.221
C04639PubChem0.71326.197
polyuridylic acidPubChem0.71324.181
pseudouridine 5'-phosphatePubChem0.71324.181