Rv2890c

Tuberculist information
Gene namerpsB
Protein function30S ribosomal protein S2 RpsB
Functional category(tuberculist)information pathways
Gene location(kb)3199.12
Molecular mass(da)31089.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 287
	  		  	1    MAVVTMKQLLDSGTHFGHQTRRWNPKMKRFIFTDRNGIYIIDLQQTLTFIDKAYEFVKET   60
			  	61   VAHGGSVLFVGTKKQAQESVAAEATRVGMPYVNQRWLGGMLTNFSTVHKRLQRLKELEAM  120
			  	121  EQTGGFEGRTKKEILGLTREKNKLERSLGGIRDMAKVPSAIWVVDTNKEHIAVGEARKLG  180
			  	181  IPVIAILDTNCDPDEVDYPIPGNDDAIRSAALLTRVIASAVAEGLQARAGLGRADGKPEA  240
			  	241  EAAEPLAEWEQELLASATASATPSATASTTALTDAPAGATEPTTDAS

Known structures in the PDB
No Known structures
1 29 57 85 113 141 169 197 225 253 281 Range: 9 to 225  |  Coverage: 75% Ribosomal_S2 Range: 6 to 231  |  Coverage: 78% 1 Range: 1 to 241  |  Coverage: 83% 1 Range: 95 to 167  |  Coverage: 25% 2
Number of amino acids : 287
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Ribosomal_S2PF003189-225
Mtb Structural Proteome models
Model Number1
Model nameRv2890c
Template1FJG    BPDBCREDO
Template coverage7_229
Template Identity(%)55.6
Model coverage(%)78.4
Normalized DOPE score-0.839

Structure Models from Chopin
Model Number1
Profilec.23.15.1
Click for model details
zscore48.15
Residue begin1
Residue end241
Model Number2
Profile1.10.287.610
Click for model details
zscore12.49
Residue begin95
Residue end167
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2890cGene nameConfidence Score
Rv2889ctsf0.999
Rv3442crpsI0.999
Rv2889ctsf0.999
Rv3443crplM0.998
Rv0721rpsE0.997
Rv0683rpsG0.997
Rv0705rpsS0.997
Rv0700rpsJ0.997
Rv0641rplA0.997
Rv0721rpsE0.997
Rv3460crpsM0.997
Rv0719rplF0.996
Rv3459crpsK0.996
Rv2882cfrr0.995
Rv0682rpsL0.995
Rv0701rplC0.995
Rv3458crpsD0.993
Rv3458crpsD0.993
Rv1641infC0.992
Rv1641infC0.992
Rv0702rplD0.991
Rv1643rplT0.991
Rv2785crpsO0.991
Rv0716rplE0.99
Rv0707rpsC0.99
Rv0704rplB0.99
Rv0704rplB0.99
Rv0716rplE0.99
Rv0707rpsC0.99
Rv0652rplL0.989
Rv0710rpsQ0.989
Rv1630rpsA0.988
Rv0053rpsF0.987
Rv0651rplJ0.987
Rv0708rplP0.985
Rv0714rplN0.985
Rv0684fusA10.984
Rv0684fusA10.984
Rv0684fusA10.984
Rv0684fusA10.984
Rv0684fusA10.984
Rv0685tuf0.983
Rv0685tuf0.983
Rv0685tuf0.983
Rv3457crpoA0.981
Rv3457crpoA0.981
Rv3457crpoA0.981
Rv0718rpsH0.98
Rv0640rplK0.98
Rv0640rplK0.98
Rv2412rpsT0.977
Rv2909crpsP0.974
Rv2883cpyrH0.974
Rv0706rplV0.974
Rv3456crplQ0.972
Rv0703rplW0.97
Rv0350dnaK0.969
Rv0056rplI0.968
Rv0056rplI0.968
Rv2056crpsN20.968
Rv0717rpsN10.967
Rv2839cinfB0.966
Rv2839cinfB0.966
Rv2839cinfB0.966
Rv2839cinfB0.966
Rv2442crplU0.966
Rv0723rplO0.964
Rv0720rplR0.964
Rv0715rplX0.963
Rv2904crplS0.957
Rv2462ctig0.956
Rv2534cefp0.956
Rv2534cefp0.956
Rv2534cefp0.956
Rv2845cproS0.956
Rv2462ctig0.956
Rv2845cproS0.956
Rv2462ctig0.956
Rv2845cproS0.956
Rv2916cffh0.951
Rv2916cffh0.951
Rv2916cffh0.951
Rv3240csecA10.949
Rv3240csecA10.949
Rv3240csecA10.949
Rv3462cinfA0.944
Rv2441crpmA0.944
Rv2906ctrmD0.944
Rv3100csmpB0.943
Rv0667rpoB0.942
Rv0667rpoB0.942
Rv0667rpoB0.942
Rv0667rpoB0.942
Rv0667rpoB0.942
Rv0667rpoB0.942
Rv2361cRv2361c0.941
Rv2992cgltS0.938
Rv1023eno0.935
Rv1023eno0.935
Rv1298rpmE0.925
Rv1292argS0.918
Rv1292argS0.918
Rv1292argS0.918
Rv1015crplY0.916
Rv1015crplY0.916
Rv1713engA0.915
Rv1713engA0.915
Rv0440groEL20.909
Rv0639nusG0.908
Rv0639nusG0.908
Rv0055rpsR10.908
Rv0722rpmD0.906
Rv2753cdapA0.902
Rv1699pyrG0.901
Rv1699pyrG0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
magnesiumPubChem0.78824.305
spectinomycinPubChem0.788332.35
guanosine diphosphatePubChem0.788443.201
5-methylcytidylic acidPubChem0.704337.223
adenosine 3',5'-diphosphatePubChem0.704427.201
[3,4-dihydroxy-5-(6-imino-1-methyl-purin-9-yl)oxolan-2-yl]methoxyphosphonic AcidPubChem0.704361.248
pactamycinPubChem0.704558.623
adenosine monophosphatePubChem0.704347.221
C04639PubChem0.704326.197
polyuridylic acidPubChem0.704324.181
pseudouridine 5'-phosphatePubChem0.704324.181
CSIPubChem0.704172.185
kasugamycinPubChem0.704379.363
2,3-diaminopropionic acidPubChem0.704104.108
phenylalaninalPubChem0.704149.19
MYC-8003PubChem0.704796.943
7mgPubChem0.704379.263
UD29PubChem0.704340.247
kirromycinPubChem0.704796.943
[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl phosphatePubChem0.704338.208
2'-O-methylguanosine 5'-monophosphatePubChem0.704377.247
potassiumPubChem0.70439.0983
L-2,3-diaminopropionic acidPubChem0.704104.108
[5-(2-dimethylamino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic AcidPubChem0.704391.274
streptomycinPubChem0.704581.574
3'-phosphoadenosine 5'-phosphatePubChem0.704427.201
poly(2'-O-methylcytidylic acid)PubChem0.704337.223
pseudouridylic acidPubChem0.704324.181
L-beta-lysinePubChem0.704146.188
DB08185PubChem0.704463.446
zincPubChem0.70465.409
poly CPubChem0.704323.197
3'-amino-3'-deoxy AMPPubChem0.704346.236
2-mercaptoethanolPubChem0.70478.1334
CHEBI:603702PubChem0.704558.623
poly(2'-O-methyladenylic acid)PubChem0.704361.248
beta-lysinePubChem0.704146.188
methyl 4-[3-[3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]-4,6-dimethyl-9-oxoimidazo[1,2-a]purin-PubChem0.704588.462
fusidic acidPubChem0.704516.709
[(2R,3S,4R,5R)-5-[2-(dimethylamino)-6-oxo-3H-purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen PubChem0.704391.274
ara-TMPPubChem0.704338.208
guanylatePubChem0.704363.221
potassium hydridePubChem0.70440.1062
[3,4-dihydroxy-5-(2-methylamino-6-oxo-3H-purin-9-yl)oxolan-2-yl]methoxyphosphonic AcidPubChem0.704377.247
guanylyl-(alpha,beta)-methylene-diphosphonatePubChem0.704521.208
C07026PubChem0.704346.236