Rv2845c

Tuberculist information
Gene nameproS
Protein functionProbable prolyl-tRNA synthetase ProS (proline--tRNA ligase) (PRORS) (global RNA synthesis factor) (proline translase)
Functional category(tuberculist)information pathways
Gene location(kb)3151.2
Molecular mass(da)63269.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 582
	  		  	1    VITRMSELFLRTLRDDPADAEVASHKLLIRAGYIRPVAPGLYSWLPLGLRVLRNIERVIR   60
			  	61   DEMNAIGGQEILFPALLPRAPYETTNRWTQYGDSVFRLKDRRGNDYLLGPTHEELFTLTV  120
			  	121  KGEYSSYKDFPLTLYQIQTKYRDEARPRAGILRAREFVMKDSYSFDIDAAGLKAAYHAHR  180
			  	181  EAYQRIFDRLQVRYVIVSAVSGAMGGSASEEFLAESPSGEDAFVRCLESGYAANVEAVVT  240
			  	241  ARPDTLPIDGLPEAVVHDTGDTPTIASLVAWANEADLGRTVTAADTLKNVLIKVRQPGGD  300
			  	301  TELLAIGVPGDREVDDKRLGAALEPADYALLDDDDFAKHPFLVKGYIGPKALRENNVRYL  360
			  	361  VDPRIVDGTSWITGADQPGRHVVGLVAGRDFTADGTIEAAEVREGDPSPDGAGPLVMARG  420
			  	421  IEIGHIFQLGSKYTDAFTADVLGEDGKPVRLTMGSYGIGVSRLVAVVAEQHHDELGLRWP  480
			  	481  STVAPFDVHLVIANKDAQARAGATALAADLDRLGVEVLLDDRQASPGVKFKDAELLGMPW  540
			  	541  IVVVGRGWADGVVELRDRFSGQTRELVAGASLATDIAAAVTG

Known structures in the PDB
No Known structures
1 59 117 175 233 291 349 407 465 523 581 Range: 51 to 221  |  Coverage: 29% tRNA-synt_2b Range: 259 to 391  |  Coverage: 22% tRNA_edit Range: 485 to 578  |  Coverage: 15% HGTP_anticodon Range: 30 to 581  |  Coverage: 94% 1 Range: 472 to 582  |  Coverage: 18% 1 Range: 259 to 391  |  Coverage: 22% 2
Number of amino acids : 582
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
tRNA-synt_2bPF0058751-221
tRNA_editPF04073259-391
HGTP_anticodonPF03129485-578
Mtb Structural Proteome models
Model Number1
Model nameRv2845c
Template1ATI    APDBCREDO
Template coverage14_504
Template Identity(%)20.3
Model coverage(%)94.7
Normalized DOPE score1.446

Structure Models from Chopin
Model Number1
Profilec.51.1.1
Click for model details
zscore12.91
Residue begin472
Residue end582
Model Number2
Profiled.116.1.1 - 3.90.960.10
Click for model details
zscore11.64
Residue begin259
Residue end391
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2845cGene nameConfidence Score
Rv2992cgltS0.958
Rv2890crpsB0.956
Rv2882cfrr0.952
Rv2839cinfB0.951
Rv2839cinfB0.951
Rv2839cinfB0.951
Rv2839cinfB0.951
Rv3580ccysS10.941
Rv3580ccysS10.941
Rv1649pheS0.927
Rv1649pheS0.927
Rv2572caspS0.926
Rv2572caspS0.926
Rv2572caspS0.926
Rv1007cmetS0.915
Rv1292argS0.915
Rv1292argS0.915
Rv1292argS0.915
Rv2580chisS0.909
Rv2580chisS0.909
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
adenosine triphosphatePubChem0.977507.181
pyrophosphatePubChem0.9177.975
adenosine monophosphatePubChem0.9347.221
L-prolinePubChem0.9115.13