Rv3580c

Tuberculist information
Gene namecysS1
Protein functionCysteinyl-tRNA synthetase 1 CysS1 (cysteine--tRNA ligase 1) (CYSRS 1) (cysteine translase)
Functional category(tuberculist)information pathways
Gene location(kb)4022.39
Molecular mass(da)51822.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 469
	  		  	1    VTDRARLRLHDTAAGVVRDFVPLRPGHVSIYLCGATVQGLPHIGHVRSGVAFDILRRWLL   60
			  	61   ARGYDVAFIRNVTDIEDKILAKAAAAGRPWWEWAATHERAFTAAYDALDVLPPSAEPRAT  120
			  	121  GHITQMIEMIERLIQAGHAYTGGGDVYFDVLSYPEYGQLSGHKIDDVHQGEGVAAGKRDQ  180
			  	181  RDFTLWKGEKPGEPSWPTPWGRGRPGWHLECSAMARSYLGPEFDIHCGGMDLVFPHHENE  240
			  	241  IAQSRAAGDGFARYWLHNGWVTMGGEKMSKSLGNVLSMPAMLQRVRPAELRYYLGSAHYR  300
			  	301  SMLEFSETAMQDAVKAYVGLEDFLHRVRTRVGAVCPGDPTPRFAEALDDDLSVPIALAEI  360
			  	361  HHVRAEGNRALDAGDHDGALRSASAIRAMMGILGCDPLDQRWESRDETSAALAAVDVLVQ  420
			  	421  AELQNREKAREQRNWALADEIRGRLKRAGIEVTDTADGPQWSLLGGDTK

Known structures in the PDB
No Known structures
1 47 93 139 185 231 277 323 369 415 461 Range: 19 to 315  |  Coverage: 63% tRNA-synt_1e Range: 342 to 405  |  Coverage: 13% DALR_2 Range: 7 to 403  |  Coverage: 84% 1 Range: 1 to 465  |  Coverage: 98% 2 Range: 307 to 394  |  Coverage: 18% 1
Number of amino acids : 469
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
tRNA-synt_1ePF0140619-315
DALR_2PF09190342-405
Mtb Structural Proteome models
Model Number1
Model nameRv3580c
Template1LI5    APDBCREDO
Template coverage2_401
Template Identity(%)43.8
Model coverage(%)84.4
Normalized DOPE score-0.732

Model Number2
Model nameRv3580c.1
Template1FFY    APDBCREDO
Template coverage20_844
Template Identity(%)15.5
Model coverage(%)98.9
Normalized DOPE score0.817

Structure Models from Chopin
Model Number1
Profile1.20.120.640
Click for model details
zscore8.92
Residue begin307
Residue end394
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3580cGene nameConfidence Score
Rv2992cgltS0.982
Rv2614cthrS0.974
Rv2614cthrS0.974
Rv2614cthrS0.974
Rv2335cysE0.971
Rv3834cserS0.971
Rv3834cserS0.971
Rv2335cysE0.971
Rv3579cRv3579c0.97
Rv3579cRv3579c0.97
Rv2448cvalS0.968
Rv2448cvalS0.968
Rv2448cvalS0.968
Rv3581cispF0.967
Rv3582cispD0.965
Rv2845cproS0.941
Rv2845cproS0.941
Rv2845cproS0.941
Rv1292argS0.935
Rv1292argS0.935
Rv1292argS0.935
Rv0041leuS0.924
Rv0041leuS0.924
Rv0041leuS0.924
Potential ligand/drug binding sites
Protein ModelPocket NumberDrug Binding Site PMIN ScorePvalue PMINPMAX ScorePvalue PMAX
Rv3580c.1303bjw_SVR_C_505PDBCREDO0.5460.2490.5180.008
Rv3580c.1303bjw_SVR_G_506PDBCREDO0.5250.2810.5110.009
Rv3580c.1301t46_STI_A_3PDBCREDO0.5220.2850.5080.010
Rv3580c.1302xkw_P1B_A_1478PDBCREDO0.5320.2700.5050.010
Rv3580c.1303bjw_SVR_B_512PDBCREDO0.5140.2970.5000.011
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
half-cystinePubChem0.949121.158
pyrophosphatePubChem0.907177.975
adenosine triphosphatePubChem0.9507.181
adenosine monophosphatePubChem0.9347.221
CysteinylPubChem0.8281648.9