Rv3581c

Tuberculist information
Gene nameispF
Protein functionProbable 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)4023.87
Molecular mass(da)16425.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 159
	  		  	1    VNQLPRVGLGTDVHPIEPGRPCWLVGLLFPSADGCAGHSDGDVAVHALCDAVLSAAGLGD   60
			  	61   IGEVFGVDDPRWQGVSGADMLRHVVVLITQHGYRVGNAVVQVIGNRPKIGWRRLEAQAVL  120
			  	121  SRLLNAPVSVSATTTDGLGLTGRGEGLAAIATALVVSLR

Known structures in the PDB
No Known structures
1 16 31 46 61 76 91 106 121 136 151 Range: 5 to 158  |  Coverage: 96% YgbB Range: 6 to 157  |  Coverage: 94% 1 Range: 1 to 159  |  Coverage: 99% 1
Number of amino acids : 159
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
YgbBPF025425-158
Mtb Structural Proteome models
Model Number1
Model nameRv3581c
Template1GX1    APDBCREDO
Template coverage2_156
Template Identity(%)42.1
Model coverage(%)95.0
Normalized DOPE score-0.996

Structure Models from Chopin
Model Number1
Profiled.79.5.1 - 3.30.1330.50
Click for model details
zscore38.91
Residue begin1
Residue end159
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3581cGene nameConfidence Score
Rv2868cgcpE0.999
Rv3582cispD0.999
Rv1011ispE0.998
Rv1011ispE0.998
Rv2870cdxr0.988
Rv2870cdxr0.988
Rv2870cdxr0.988
Rv1110lytB20.987
Rv2682cdxs10.981
Rv2682cdxs10.981
Rv2682cdxs10.981
Rv3580ccysS10.967
Rv3580ccysS10.967
Rv3382clytB10.966
Rv3583cRv3583c0.952
Rv2992cgltS0.927
Rv3579cRv3579c0.914
Rv3579cRv3579c0.914
Rv2906ctrmD0.912
Rv3379cdxs20.904
Rv3379cdxs20.904
Rv3379cdxs20.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
2-C-methyl-D-erythritol 2,4-cyclodiphosphatePubChem0.996278.091
2-C-methyl-D-erythritol-2,4-cyclopyrophosphatePubChem0.996278.091
C11436PubChem0.967601.287
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritolPubChem0.947521.307
isopentenyl diphosphatePubChem0.919246.092
1-deoxy-D-xylulose 5-phosphatePubChem0.869214.11
pyrophosphatePubChem0.857177.975
glycerolPubChem0.85292.0938
cytidinePubChem0.825243.217
zincPubChem0.81165.409
magnesiumPubChem0.80924.305
chloridePubChem0.80535.453
poly CPubChem0.8323.197
selenomethioninePubChem0.8196.106
SeMetPubChem0.8196.106
cytidine diphosphatePubChem0.8403.176
sulfatePubChem0.79896.0626
acetatePubChem0.79859.044
hydron sulfatePubChem0.798196.157
hydride acetatePubChem0.79861.0599
cytosine arabinosidePubChem0.792243.217
cobaltPubChem0.786117.866
hydron; phosphonato phosphatePubChem0.785175.959
manganesePubChem0.78554.938
cytidine triphosphatePubChem0.784483.156
ara-CTPPubChem0.784483.156
dimethylallyl diphosphatePubChem0.768246.092
ethylene glycol; hydronPubChem0.74563.0758
polyethylene glycolPubChem0.74562.0678
phosphatePubChem0.74496.9872
geranyl diphosphatePubChem0.742314.209
cytosinePubChem0.736111.102