Rv3579c

Tuberculist information
Gene nameRv3579c
Protein functionPossible tRNA/rRNA methyltransferase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)4021.43
Molecular mass(da)34009.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 322
	  		  	1    MPGNSRRRGAVRKSGTKKGAGVGSGGQRRRGLEGRGPTPPAHLRPHHPAAKRARAQPRRP   60
			  	61   VKRADETETVLGRNPVLECLRAGVPATALYVALGTEADERLTECVARAADSGIAIVELLR  120
			  	121  ADLDRMTANHLHQGIALQVPPYNYAHPDDLLAAALDQPPALLVALDNLSDPRNLGAIVRS  180
			  	181  VAAFGGHGVLIPQRRSASVTAVAWRTSAGAAARIPVARATNLTRTLKGWADRGVRVIGLD  240
			  	241  AGGGTALDDVDGTDSLVVVVGSEGKGLSRLVRQNCDEVVSIPMAAQAESLNASVAAGVVL  300
			  	301  AEIARQRRRPREPREQTQNRMI

Known structures in the PDB
No Known structures
1 33 65 97 129 161 193 225 257 289 321 Range: 69 to 145  |  Coverage: 23% SpoU_sub_bind Range: 160 to 301  |  Coverage: 43% SpoU_methylase Range: 67 to 307  |  Coverage: 74% 1 Range: 140 to 309  |  Coverage: 52% 1 Range: 40 to 310  |  Coverage: 83% 2 Range: 69 to 141  |  Coverage: 22% 3 Range: 36 to 180  |  Coverage: 44% 4
Number of amino acids : 322
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
SpoU_sub_bindPF0803269-145
SpoU_methylasePF00588160-301
Mtb Structural Proteome models
Model Number1
Model nameRv3579c
Template1GZ0    APDBCREDO
Template coverage2_242
Template Identity(%)35.3
Model coverage(%)74.5
Normalized DOPE score-0.705

Structure Models from Chopin
Model Number1
Profilec.116.1.1
Click for model details
zscore41.82
Residue begin140
Residue end309
Model Number2
Profilec.116.1.1, d.79.3.3 - 3.30.1330.30, 3.40.1280.10
Click for model details
zscore38.3
Residue begin40
Residue end310
Model Number3
Profiled.79.3.3
Click for model details
zscore17.06
Residue begin69
Residue end141
Model Number4
Profile3.30.1330.30
Click for model details
zscore8.71
Residue begin36
Residue end180
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3579cGene nameConfidence Score
Rv3580ccysS10.97
Rv3580ccysS10.97
Rv3581cispF0.914
Rv3582cispD0.906
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
tetrahydrofolatePubChem0.9445.429
5-methyltetrahydrofolatePubChem0.9459.456
an aldehydePubChem0.930.026
carbon monoxidePubChem0.928.0101
Co-APubChem0.9767.534
methanolPubChem0.930.026
N5,N10-methylenetetrahydrofolatePubChem0.9457.44
5,10-methylenetetrahydrofolatePubChem0.9457.44
protiumPubChem0.92.01576
acetyl coenzyme-APubChem0.9809.571
acetyl-CoAPubChem0.9809.571
H(+)PubChem0.92.01588
coenzyme APubChem0.9767.534
methyltetrahydrofolatePubChem0.9459.456
deuteriumPubChem0.92.01588
H4FPubChem0.9445.429