Rv3379c

Tuberculist information
Gene namedxs2
Protein functionProbable 1-deoxy-D-xylulose 5-phosphate synthase Dxs2 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3793.26
Molecular mass(da)57148.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 536
	  		  	1    VFDTGHQTYPHKLLTGRGKDFATLRQADGLSGYPNRHESPHDWVENSHASVSLAWVDGIA   60
			  	61   KALALQGQCDRRVIAVIGDGALTGGVAWEGLNNLGAATRPVIVVLNDNGRSYDPTAGALA  120
			  	121  AHLEELRVGTPRGPNLFENMGFTYIGPVDGHNIPDTCAVLRKAAAAARPVVVHAVTSKGR  180
			  	181  GYPPAEADERDHMHACGVVDIATGLASTPSQRSWTDVFEDEIARIADDRSDVVGLTAAMR  240
			  	241  LPTGLGALSRRYPHRVFDSGIAEQHLLASAAGLAAAGTHPVVAVYSTFLHRAFDQLLFDI  300
			  	301  GLHRLPVTLVLDRAGVTGPDGPSHHGLWDLALLACVPGFQIACPRDAPRLRQQLRTAIAT  360
			  	361  AAPTAVRFPKGAPGEPITAEHTIGGLDVLHTPPPHWRPDVLLVAVGAMSRPCMDAARCLS  420
			  	421  EEQIGVTVVDPQWVWPISPALTELAGRHRITVCVEDAIADVGIGAHLSHHIGRTHPRTRT  480
			  	481  YTLGLPPAYIPHASRDHILSSHGLTGPAIRIRCKSLLNALHEVPGPEDHPDSGDSY

Known structures in the PDB
No Known structures
1 54 107 160 213 266 319 372 425 478 531 Range: 1 to 133  |  Coverage: 24% DXP_synthase_N Range: 127 to 176  |  Coverage: 9% DXP_synthase_N Range: 210 to 375  |  Coverage: 30% Transket_pyr Range: 390 to 509  |  Coverage: 22% Transketolase_C Range: 1 to 536  |  Coverage: 99% 1 Range: 210 to 375  |  Coverage: 30% 1 Range: 390 to 509  |  Coverage: 22% 2 Range: 29 to 174  |  Coverage: 27% 3 Range: 59 to 232  |  Coverage: 32% 4
Number of amino acids : 536
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
DXP_synthase_NPF132921-133
DXP_synthase_NPF13292127-176
Transket_pyrPF02779210-375
Transketolase_CPF02780390-509
Mtb Structural Proteome models
Model Number1
Model nameRv3379c
Template1R9J    APDBCREDO
Template coverage61_668
Template Identity(%)18.7
Model coverage(%)99.8
Normalized DOPE score0.557

Structure Models from Chopin
Model Number1
Profilec.36.1.6
Click for model details
zscore23.79
Residue begin210
Residue end375
Model Number2
Profilec.48.1.2
Click for model details
zscore15.09
Residue begin390
Residue end509
Model Number3
Profilec.36.1.10
Click for model details
zscore9.51
Residue begin29
Residue end174
Model Number4
Profilec.36.1.10
Click for model details
zscore9.05
Residue begin59
Residue end232
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3379cGene nameConfidence Score
Rv2870cdxr0.998
Rv2870cdxr0.998
Rv2870cdxr0.998
Rv2868cgcpE0.949
Rv3382clytB10.947
Rv3378cRv3378c0.94
Rv3383cidsB0.938
Rv3377cRv3377c0.916
Rv3581cispF0.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
1-deoxy-D-xylulose 5-phosphatePubChem0.978214.11
D-glyceraldehyde-3-phosphatePubChem0.933170.058