Rv3378c

Tuberculist information
Gene nameRv3378c
Protein functionDiterpene synthase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3792.36
Molecular mass(da)34030.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 296
	  		  	1    MNLVSEKEFLDLPLVSVAEIVRCRGPKVSVFPFDGTRRWFHLECNPQYDDYQQAALRQSI   60
			  	61   RILKMLFEHGIETVISPIFSDDLLDRGDRYIVQALEGMALLANDEEILSFYKEHEVHVLF  120
			  	121  YGDYKKRLPSTAQGAAVVKSFDDLTISTSSNTEHRLCFGVFGNDAAESVAQFSISWNETH  180
			  	181  GKPPTRREIIEGYYGEYVDKADMFIGFGRFSTFDFPLLSSGKTSLYFTVAPSYYMTETTL  240
			  	241  RRILYDHIYLRHFRPKPDYSAMSADQLNVLRNRYRAQPDRVFGVGCVHDGIWFAEG

Known structures in the PDB
PDB ID3WQK
Total residue count296
Number of chains1
MethodX-RAY
Resolution2.3
PDB ID3WQL
Total residue count1184
Number of chains4
MethodX-RAY
Resolution2.1
PDB ID3WQM
Total residue count301
Number of chains1
MethodX-RAY
Resolution2.1
PDB ID3WQN
Total residue count297
Number of chains1
MethodX-RAY
Resolution2.7
PDB ID4CMV
Total residue count592
Number of chains2
MethodX-RAY
Resolution2.31
PDB ID4CMW
Total residue count592
Number of chains2
MethodX-RAY
Resolution2.21
PDB ID4CMX
Total residue count592
Number of chains2
MethodX-RAY
Resolution2.36
PDB ID4KT8
Total residue count296
Number of chains1
MethodX-RAY
Resolution2.4
1 30 59 88 117 146 175 204 233 262 291 Range: 32 to 244  |  Coverage: 71% Prenyltransf Range: 22 to 244  |  Coverage: 75% 1 Range: 20 to 281  |  Coverage: 88% 1
Number of amino acids : 296
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PrenyltransfPF0125532-244
Mtb Structural Proteome models
Model Number1
Model nameRv3378c
Template1UEH    APDBCREDO
Template coverage14_233
Template Identity(%)18.0
Model coverage(%)74.7
Normalized DOPE score0.266

Structure Models from Chopin
Model Number1
Profilec.101.1.1 - 3.40.1180.10
Click for model details
zscore5.78
Residue begin20
Residue end281
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3378cGene nameConfidence Score
Rv3377cRv3377c0.984
Rv3379cdxs20.94
Rv3379cdxs20.94
Rv3379cdxs20.94
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
tuberculosinolPubChem0.722290.483
tuberculosinyl diphosphatePubChem0.701450.443