Rv3377c

Tuberculist information
Gene nameRv3377c
Protein functionHalimadienyl diphosphate synthase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3790.85
Molecular mass(da)55262.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 501
	  		  	1    METFRTLLAKAALGNGISSTAYDTAWVAKLGQLDDELSDLALNWLCERQLPDGSWGAEFP   60
			  	61   FCYEDRLLSTLAAMISLTSNKHRRRRAAQVEKGLLALKNLTSGAFEGPQLDIKDATVGFE  120
			  	121  LIAPTLMAEAARLGLAICHEESILGELVGVREQKLRKLGGSKINKHITAAFSVELAGQDG  180
			  	181  VGMLDVDNLQETNGSVKYSPSASAYFALHVKPGDKRALAYISSIIQAGDGGAPAFYQAEI  240
			  	241  FEIVWSLWNLSRTDIDLSDPEIVRTYLPYLDHVEQHWVRGRGVGWTGNSTLEDCDTTSVA  300
			  	301  YDVLSKFGRSPDIGAVLQFEDADWFRTYFHEVGPSISTNVHVLGALKQAGYDKCHPRVRK  360
			  	361  VLEFIRSSKEPGRFCWRDKWHRSAYYTTAHLICAASNYDDALCSDAIGWILNTQRPDGSW  420
			  	421  GFFDGQATAEETAYCIQALAHWQRHSGTSLSAQISRAGGWLSQHCEPPYAPLWIAKTLYC  480
			  	481  SATVVKAAILSALRLVDESNQ

Known structures in the PDB
No Known structures
1 51 101 151 201 251 301 351 401 451 501 Range: 275 to 421  |  Coverage: 29% Prenyltrans_2 Range: 1 to 501  |  Coverage: 99% 1
Number of amino acids : 501
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Prenyltrans_2PF13249275-421
Mtb Structural Proteome models
Model Number1
Model nameRv3377c
Template2SQC    APDBCREDO
Template coverage15_630
Template Identity(%)17.4
Model coverage(%)99.8
Normalized DOPE score0.502

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3377cGene nameConfidence Score
Rv3378cRv3378c0.984
Rv3379cdxs20.916
Rv3379cdxs20.916
Rv3379cdxs20.916
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
tuberculosinolPubChem0.728290.483
tuberculosinyl diphosphatePubChem0.728450.443