Rv3383c

Tuberculist information
Gene nameidsB
Protein functionPossible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)3797.44
Molecular mass(da)36431.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 350
	  		  	1    MGGVLTLDAAFLGSVPADLGKALLERARADCGPVLHRAIESMREPLATMAGYHLGWWNAD   60
			  	61   RSTAAGSSGKYFRAALVYAAAAACGGDVGDATPVSAAVELVHNFTLLHDDVMDGDATRRG  120
			  	121  RPTVWSVWGVGVAILLGDALHATAVRILTGLTDECVAVRAIRRLQMSCLDLCIGQFEDCL  180
			  	181  LEGQPEVTVDDYLRMAAGKTAALTGCCCALGALVANADDATIAALERFGHELGLAFQCVD  240
			  	241  DLIGIWGDPGVTGKPVGNDLARRKATLPVVAALNSRSEAATELAALYQAPAAMTASDVER  300
			  	301  ATALVKVAGGGHVAQRCADERIQAAIAALPDAVRSPDLIALSQLICRREC

Known structures in the PDB
No Known structures
1 36 71 106 141 176 211 246 281 316 351 Range: 57 to 307  |  Coverage: 71% polyprenyl_synt Range: 25 to 349  |  Coverage: 92% 1 Range: 6 to 350  |  Coverage: 98% 1
Number of amino acids : 350
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
polyprenyl_syntPF0034857-307
Mtb Structural Proteome models
Model Number1
Model nameRv3383c
Template1WY0    APDBCREDO
Template coverage2_341
Template Identity(%)30.5
Model coverage(%)92.6
Normalized DOPE score-0.277

Structure Models from Chopin
Model Number1
Profile1.10.600.10
Click for model details
zscore35.03
Residue begin6
Residue end350
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3383cGene nameConfidence Score
Rv3382clytB10.998
Rv1086Rv10860.953
Rv1745cidi0.946
Rv3379cdxs20.938
Rv3379cdxs20.938
Rv3379cdxs20.938
Rv0989cgrcC20.934
Rv2173idsA20.93
Rv0562grcC10.93
Rv1110lytB20.928
Rv3398cidsA10.917
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
isopentenyl diphosphatePubChem0.963246.092
farnesyl diphosphatePubChem0.949382.326
geranylgeranyl pyrophosphatePubChem0.948450.443
dimethylallyl diphosphatePubChem0.946246.092
pyrophosphatePubChem0.944177.975
geranyl diphosphatePubChem0.926314.209
undecaprenyl diphosphatePubChem0.909927.262
undecaprenyl pyrophosphatePubChem0.907927.262
octaprenyl pyrophosphatePubChem0.9722.911