Rv3398c

Tuberculist information
Gene nameidsA1
Protein functionProbable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate synthase): dimethylallyltransferase (prenyltransferase) (geranyl-diphosphate synthase) + geranyltranstransferase (farnesyl-diphosphate synthase) (farnesyl-pyrophosphate synthetase) (farnesyl diphosphate synthetase) (FPP synthetase) + farnesyltranstransferase (geranylgeranyl-diphosphate synthase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)3815.03
Molecular mass(da)38852.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 359
	  		  	1    MRGTDEKYGLPPQPDSDRMTRRTLPVLGLAHELITPTLRQMADRLDPHMRPVVSYHLGWS   60
			  	61   DERGRPVNNNCGKAIRPALVFVAAEAAGADPHSAIPGAVSVELVHNFSLVHDDLMDRDEH  120
			  	121  RRHRPTVWALWGDAMALLAGDAMLSLAHEVLLDCDSPHVGAALRAISEATRELIRGQAAD  180
			  	181  TAFESRTDVALDECLKMAEGKTAALMAASAEVGALLAGAPRSVREALVAYGRHIGLAFQL  240
			  	241  VDDLLGIWGRPEITGKPVYSDLRSRKKTLPVTWTVAHGGSAGRRLAAWLVDETGSQTASD  300
			  	301  DELAAVAELIECGGGRRWASAEARRHVTQGIDMVARIGIPDRPAAELQDLAHYIVDRQA

Known structures in the PDB
No Known structures
1 36 71 106 141 176 211 246 281 316 351 Range: 62 to 318  |  Coverage: 71% polyprenyl_synt Range: 29 to 358  |  Coverage: 91% 1 Range: 8 to 359  |  Coverage: 97% 1
Number of amino acids : 359
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
polyprenyl_syntPF0034862-318
Mtb Structural Proteome models
Model Number1
Model nameRv3398c
Template1WY0    APDBCREDO
Template coverage2_341
Template Identity(%)33.6
Model coverage(%)91.6
Normalized DOPE score-0.358

Structure Models from Chopin
Model Number1
Profilea.128.1.1 - 1.10.600.10
Click for model details
zscore32.09
Residue begin8
Residue end359
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3398cGene nameConfidence Score
Rv1086Rv10860.983
Rv3397cphyA0.982
Rv1745cidi0.94
Rv2173idsA20.935
Rv0562grcC10.934
Rv0989cgrcC20.934
Rv1110lytB20.932
Rv3382clytB10.929
Rv3383cidsB0.917
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
isopentenyl diphosphatePubChem0.985246.092
dimethylallyl diphosphatePubChem0.977246.092
farnesyl diphosphatePubChem0.976382.326
geranyl diphosphatePubChem0.967314.209
geranylgeranyl pyrophosphatePubChem0.954450.443
pyrophosphatePubChem0.939177.975
undecaprenyl diphosphatePubChem0.913927.262
undecaprenyl pyrophosphatePubChem0.911927.262
octaprenyl pyrophosphatePubChem0.9722.911