Rv3397c

Tuberculist information
Gene namephyA
Protein functionProbable phytoene synthase PhyA
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3814.09
Molecular mass(da)33141.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 302
	  		  	1    MTEIEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETK   60
			  	61   ITELDAIRKSLDNIDDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDE  120
			  	121  LIVYCRRGAGTIGKLCLSIFGPVSTATSRYAEQLGIALQQTNILRDVREDFLNGRIYLPR  180
			  	181  DELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAACCAA  240
			  	241  MSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALASSVTCGPAHGPLPADLGSHP  300
			  	301  SH

Known structures in the PDB
No Known structures
1 31 61 91 121 151 181 211 241 271 301 Range: 15 to 270  |  Coverage: 84% SQS_PSY Range: 6 to 295  |  Coverage: 95% 1 Range: 2 to 302  |  Coverage: 99% 1
Number of amino acids : 302
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
SQS_PSYPF0049415-270
Mtb Structural Proteome models
Model Number1
Model nameRv3397c
Template1EZF    APDBCREDO
Template coverage38_352
Template Identity(%)18.6
Model coverage(%)95.7
Normalized DOPE score-0.113

Structure Models from Chopin
Model Number1
Profilea.128.1.2 - 1.10.600.10
Click for model details
zscore35.41
Residue begin2
Residue end302
Binding pockets
STRING
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Protein interacting with Rv3397cGene nameConfidence Score
Rv3398cidsA10.982
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
geranylgeranyl pyrophosphatePubChem0.969450.443
pyrophosphatePubChem0.925177.975
prephytoene diphosphatePubChem0.9722.911
prelycopersene pyrophosphatePubChem0.9722.911
phytoenePubChem0.787544.936
lycopenePubChem0.719536.873