Rv1745c

Tuberculist information
Gene nameidi
Protein functionProbable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1971.38
Molecular mass(da)22489.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 203
	  		  	1    MTRSYRPAPPIERVVLLNDRGDATGVADKATVHTGDTPLHLAFSSYVFDLHDQLLITRRA   60
			  	61   ATKRTWPAVWTNSCCGHPLPGESLPGAIRRRLAAELGLTPDRVDLILPGFRYRAAMADGT  120
			  	121  VENEICPVYRVQVDQQPRPNSDEVDAIRWLSWEQFVRDVTAGVIAPVSPWCRSQLGYLTK  180
			  	181  LGPCPAQWPVADDCRLPKAAHGN

Known structures in the PDB
No Known structures
1 21 41 61 81 101 121 141 161 181 201 Range: 39 to 174  |  Coverage: 66% NUDIX Range: 39 to 179  |  Coverage: 68% 1 Range: 9 to 193  |  Coverage: 90% 1
Number of amino acids : 203
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NUDIXPF0029339-174
Mtb Structural Proteome models
Model Number1
Model nameRv1745c
Template1HZT    APDBCREDO
Template coverage31_170
Template Identity(%)44.3
Model coverage(%)69.0
Normalized DOPE score-0.984

Structure Models from Chopin
Model Number1
Profiled.113.1.2 - 3.90.79.10
Click for model details
zscore35.94
Residue begin9
Residue end193
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1745cGene nameConfidence Score
Rv2682cdxs10.956
Rv2682cdxs10.956
Rv2682cdxs10.956
Rv3383cidsB0.946
Rv1110lytB20.942
Rv1086Rv10860.941
Rv3398cidsA10.94
Rv2173idsA20.935
Rv3382clytB10.929
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
magnesiumPubChem0.9824.305
dimethylallyl diphosphatePubChem0.978246.092
isopentenyl diphosphatePubChem0.977246.092
pyrophosphatePubChem0.974177.975
geranyl diphosphatePubChem0.904314.209
manganesePubChem0.78754.938
SeMetPubChem0.785196.106
selenomethioninePubChem0.785196.106
hydron; phosphonato phosphatePubChem0.744175.959
sulfatePubChem0.796.0626
hydron sulfatePubChem0.7196.157