Rv2173

Tuberculist information
Gene nameidsA2
Protein functionProbable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)2434.85
Molecular mass(da)37762.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 352
	  		  	1    LAGAITDQLRRYLHGRRRAAAHMGSDYDGLIADLEDFVLGGGKRLRPLFAYWGWHAVASR   60
			  	61   EPDPDVLLLFSALELLHAWALVHDDLIDRSATRRGRPTAQLRYAALHRDRDWRGSPDQFG  120
			  	121  MSAAILLGDLAQVWADDIVSKVCQSALAPDAQRRVHRVWADIRNEVLGGQYLDIVAEASA  180
			  	181  AESIESAMNVATLKTACYTVSRPLQLGTAAAADRSDVAAIFEHFGADLGVAFQLRDDVLG  240
			  	241  VFGDPAVTGKPSGDDLKSGKRTVLVAEAVELADRSDPLAAKLLRTSIGTRLTDAQVRELR  300
			  	301  TVIEAVGARAAAESRIAALTQRALATLASAPINATAKAGLSELAMMAANRSA

Known structures in the PDB
No Known structures
1 36 71 106 141 176 211 246 281 316 351 Range: 30 to 106  |  Coverage: 21% polyprenyl_synt Range: 109 to 312  |  Coverage: 57% polyprenyl_synt Range: 28 to 348  |  Coverage: 90% 1 Range: 1 to 77  |  Coverage: 21% 1 Range: 30 to 106  |  Coverage: 21% 2 Range: 109 to 185  |  Coverage: 21% 3
Number of amino acids : 352
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
polyprenyl_syntPF0034830-106
polyprenyl_syntPF00348109-312
Mtb Structural Proteome models
Model Number1
Model nameRv2173
Template1WMW    APDBCREDO
Template coverage24_323
Template Identity(%)34.7
Model coverage(%)90.7
Normalized DOPE score0.158

Structure Models from Chopin
Model Number1
Profilea.128.1.1 - 1.10.600.10
Click for model details
zscore9.18
Residue begin1
Residue end77
Model Number2
Profilea.128.1.1 - 1.10.600.10
Click for model details
zscore9.18
Residue begin30
Residue end106
Model Number3
Profilea.128.1.1 - 1.10.600.10
Click for model details
zscore9.18
Residue begin109
Residue end185
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2173Gene nameConfidence Score
Rv2174mptA0.976
Rv1086Rv10860.959
Rv0989cgrcC20.936
Rv0562grcC10.936
Rv3398cidsA10.935
Rv1745cidi0.935
Rv3383cidsB0.93
Rv1110lytB20.92
Rv3382clytB10.914
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
isopentenyl diphosphatePubChem0.931246.092
geranylgeranyl pyrophosphatePubChem0.924450.443
dimethylallyl diphosphatePubChem0.923246.092
farnesyl diphosphatePubChem0.922382.326
geranyl diphosphatePubChem0.913314.209
pyrophosphatePubChem0.911177.975
undecaprenyl diphosphatePubChem0.903927.262
undecaprenyl pyrophosphatePubChem0.902927.262
octaprenyl pyrophosphatePubChem0.9722.911