Rv0989c

Tuberculist information
Gene namegrcC2
Protein functionProbable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1106.41
Molecular mass(da)34757.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 325
	  		  	1    MIPAVSLGDPQFTANVHDGIARITELINSELSQADEVMRDTVAHLVDAGGTPFRPLFTVL   60
			  	61   AAQLGSDPDGWEVTVAGAAIELMHLGTLCHDRVVDESDMSRKTPSDNTRWTNNFAILAGD  120
			  	121  YRFATASQLASRLDPEAFAVVAEAFAELITGQMRATRGPASHIDTIEHYLRVVHEKTGSL  180
			  	181  IAASGQLGAALSGAAEEQIRRVARLGRMIGAAFEISRDIIAISGDSATLSGADLGQAVHT  240
			  	241  LPMLYALREQTPDTSRLRELLAGPIHDDHVAEALTLLRCSPGIGKAKNVVAAYAAQAREE  300
			  	301  LPYLPDRQPRRALATLIDHAISACD

Known structures in the PDB
No Known structures
1 33 65 97 129 161 193 225 257 289 321 Range: 38 to 276  |  Coverage: 73% polyprenyl_synt Range: 10 to 323  |  Coverage: 96% 1 Range: 1 to 325  |  Coverage: 99% 1
Number of amino acids : 325
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
polyprenyl_syntPF0034838-276
Mtb Structural Proteome models
Model Number1
Model nameRv0989c
Template1WY0    APDBCREDO
Template coverage5_340
Template Identity(%)27.1
Model coverage(%)96.3
Normalized DOPE score-0.902

Structure Models from Chopin
Model Number1
Profilea.128.1.1 - 1.10.600.10
Click for model details
zscore33.77
Residue begin1
Residue end325
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0989cGene nameConfidence Score
Rv2173idsA20.936
Rv3383cidsB0.934
Rv3398cidsA10.934
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
hexaprenyl diphosphatePubChem0.915586.677
C04216PubChem0.9654.794
hexaprenyl-diphosphatePubChem0.9586.677
Heptaprenyl pyrophosphatePubChem0.9654.794
decaprenyl diphosphatePubChem0.714859.145