Rv0562

Tuberculist information
Gene namegrcC1
Protein functionProbable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)652.771
Molecular mass(da)35528.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 335
	  		  	1    VRTPATVVAGVDLGDAVFAAAVRAGVARVEQLMDTELRQADEVMSDSLLHLFNAGGKRFR   60
			  	61   PLFTVLSAQIGPQPDAAAVTVAGAVIEMIHLATLYHDDVMDEAQVRRGAPSANAQWGNNV  120
			  	121  AILAGDYLLATASRLVARLGPEAVRIIADTFAQLVTGQMRETRGTSENVDSIEQYLKVVQ  180
			  	181  EKTGSLIGAAGRLGGMFSGATDEQVERLSRLGGVVGTAFQIADDIIDIDSESDESGKLPG  240
			  	241  TDVREGVHTLPMLYALRESGPDCARLRALLNGPVDDDAEVREALTLLRASPGMARAKDVL  300
			  	301  AQYAAQARHELALLPDVPGRRALAALVDYTVSRHG

Known structures in the PDB
No Known structures
1 34 67 100 133 166 199 232 265 298 331 Range: 43 to 286  |  Coverage: 72% polyprenyl_synt Range: 16 to 334  |  Coverage: 94% 1 Range: 1 to 335  |  Coverage: 99% 1
Number of amino acids : 335
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
polyprenyl_syntPF0034843-286
Mtb Structural Proteome models
Model Number1
Model nameRv0562
Template1WY0    APDBCREDO
Template coverage5_341
Template Identity(%)28.8
Model coverage(%)94.9
Normalized DOPE score-0.976

Structure Models from Chopin
Model Number1
Profile1.10.600.10
Click for model details
zscore33.83
Residue begin1
Residue end335
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0562Gene nameConfidence Score
Rv2173idsA20.936
Rv3398cidsA10.934
Rv3383cidsB0.93
Rv0534cmenA0.909
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
isopentenyl diphosphatePubChem0.982246.092
farnesyl diphosphatePubChem0.969382.326
pyrophosphatePubChem0.959177.975
hexaprenyl diphosphatePubChem0.942586.677
Heptaprenyl pyrophosphatePubChem0.902654.794
hexaprenyl-diphosphatePubChem0.9586.677
C04216PubChem0.9654.794
geranylgeranyl pyrophosphatePubChem0.745450.443