Rv0534c

Tuberculist information
Gene namemenA
Protein function1,4-dihydroxy-2-naphthoate octaprenyltransferase MenA (DHNA-octaprenyltransferase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)625.562
Molecular mass(da)29982.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 292
	  		  	1    VASFAQWVSGARPRTLPNAIAPVVAGTGAAAWLHAAVWWKALLALAVAVALVIGVNYAND   60
			  	61   YSDGIRGTDDDRVGPVRLVGSRLATPRSVLTAAMTSLALGALAGLVLALLSAPWLIAVGA  120
			  	121  ICIAGAWLYTGGSKPYGYAGFGELAVFVFFGPVAVLGTQYTQALRVDWVGLAQAVATGAL  180
			  	181  SCSVLVANNLRDIPTDARADKITLAVRLGDARTRMLYQGLLAVAGVLTFVLMLATPWCVV  240
			  	241  GLVAAPLALRAAGPVRSGRGGRELIPVLRDTGLAMLVWALAVAGALAFGQLS

Known structures in the PDB
No Known structures
1 30 59 88 117 146 175 204 233 262 291 Range: 16 to 291  |  Coverage: 94% UbiA
Number of amino acids : 292
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
UbiAPF0104016-291
Mtb Structural Proteome models
Structure models not available for this query
Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
Structure models not available for this query
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0534cGene nameConfidence Score
Rv0558menH0.981
Rv0555menD0.969
Rv0555menD0.969
Rv0548cmenB0.964
Rv3853rraA0.949
Rv0562grcC10.909
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
deuteriumPubChem0.9112.01588
S-adenosyl-methioninePubChem0.9398.437
pyrophosphatePubChem0.9177.975
S-adenosylhomocysteinePubChem0.9384.411
phytyl diphosphatePubChem0.9456.491
coenzyme APubChem0.9767.534
menaquinolPubChem0.9310.43
H(+)PubChem0.92.01588
octaprenyl pyrophosphatePubChem0.9722.911
1,4-dihydroxy-2-naphthoyl-CoAPubChem0.9953.698
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
CPD-9925PubChem0.9949.666
S-adenosyl-L-methioninePubChem0.9399.445
carbon dioxidePubChem0.944.0095
C05818PubChem0.9294.387
1,4-dihydroxy-2-naphthoic acidPubChem0.9204.179
2-phytyl-1,4-naphthoquinonePubChem0.9436.669
Co-APubChem0.9767.534