Rv0555

Tuberculist information
Gene namemenD
Protein functionProbable bifunctional menaquinone biosynthesis protein MenD : 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (SHCHC synthase) + 2-oxoglutarate decarboxylase (alpha- ketoglutarate decarboxylase) (KDC)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)646.298
Molecular mass(da)57803.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 554
	  		  	1    VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY   60
			  	61   LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM  120
			  	121  EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP  180
			  	181  LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL  240
			  	241  AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT  300
			  	301  GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA  360
			  	361  AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG  420
			  	421  AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ  480
			  	481  GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR  540
			  	541  SSLRQLHAAIKAAL

Known structures in the PDB
No Known structures
1 56 111 166 221 276 331 386 441 496 551 Range: 5 to 191  |  Coverage: 33% TPP_enzyme_N Range: 394 to 525  |  Coverage: 23% TPP_enzyme_C Range: 7 to 554  |  Coverage: 98% 1 Range: 1 to 209  |  Coverage: 37% 1
Number of amino acids : 554
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
TPP_enzyme_NPF027765-191
TPP_enzyme_CPF02775394-525
Mtb Structural Proteome models
Model Number1
Model nameRv0555
Template1OVM    APDBCREDO
Template coverage7_546
Template Identity(%)15.6
Model coverage(%)98.7
Normalized DOPE score0.113

Structure Models from Chopin
Model Number1
Profilec.36.1.5
Click for model details
zscore11.23
Residue begin1
Residue end209
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0555Gene nameConfidence Score
Rv0548cmenB0.998
Rv3215entC0.995
Rv0558menH0.975
Rv0534cmenA0.969
Rv0553menC0.946
Rv0553menC0.946
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
isochorismatePubChem0.986226.183
thiamine pyrophosphatePubChem0.984425.314
alpha-ketoglutaratePubChem0.984146.098
SHCHCPubChem0.974240.209
carbon dioxidePubChem0.92544.0095
pyruvic acidPubChem0.988.0621
CHEBI:1277PubChem0.9240.209
4-(2'-carboxyphenyl)-4-oxobutyric acidPubChem0.842222.194
menadionePubChem0.824172.18
manganesePubChem0.79954.938
1,4-dihydroxy-2-naphthoic acidPubChem0.753204.179
spirodilactonePubChem0.743204.179
Na(+)PubChem0.7122.9898