Rv0558

Tuberculist information
Gene namemenH
Protein functionProbable ubiquinone/menaquinone biosynthesis methyltransferase MenH (2-heptaprenyl-1,4-naphthoquinone methyltransferase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)649.689
Molecular mass(da)25298.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 234
	  		  	1    MSRAALDKDPRDVASMFDGVARKYDLTNTVLSLGQDRYWRRATRSALRIGPGQKVLDLAA   60
			  	61   GTAVSTVELTKSGAWCVAADFSVGMLAAGAARKVPKVAGDATRLPFGDDVFDAVTISFGL  120
			  	121  RNVANQQAALREMARVTRPGGRLLVCEFSTPTNALFATAYKEYLMRALPRVARAVSSNPE  180
			  	181  AYEYLAESIRAWPDQAVLAHQISRAGWSGVRWRNLTGGIVALHAGYKPGKQTPQ

Known structures in the PDB
No Known structures
1 24 47 70 93 116 139 162 185 208 231 Range: 5 to 227  |  Coverage: 94% Ubie_methyltran Range: 15 to 215  |  Coverage: 85% 1 Range: 8 to 234  |  Coverage: 96% 1
Number of amino acids : 234
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Ubie_methyltranPF012095-227
Mtb Structural Proteome models
Model Number1
Model nameRv0558
Template2AVN    APDBCREDO
Template coverage7_201
Template Identity(%)23.6
Model coverage(%)85.5
Normalized DOPE score0.209

Structure Models from Chopin
Model Number1
Profilec.66.1.41 - 3.40.50.150
Click for model details
zscore18.45
Residue begin8
Residue end234
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0558Gene nameConfidence Score
Rv0534cmenA0.981
Rv0555menD0.975
Rv0555menD0.975
Rv0553menC0.923
Rv0553menC0.923
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
5,10-methylenetetrahydrofolatePubChem0.924457.44
2-phytyl-1,4-naphthoquinonePubChem0.914436.669
carbon monoxidePubChem0.928.0101
Co-APubChem0.9767.534
methanolPubChem0.930.026
N5,N10-methylenetetrahydrofolatePubChem0.9457.44
protiumPubChem0.92.01576
acetyl coenzyme-APubChem0.9809.571
acetyl-CoAPubChem0.9809.571
H(+)PubChem0.92.01588
coenzyme APubChem0.9767.534
methyltetrahydrofolatePubChem0.9459.456
deuteriumPubChem0.92.01588
H4FPubChem0.9445.429
tetrahydrofolatePubChem0.9445.429
5-methyltetrahydrofolatePubChem0.9459.456
C05818PubChem0.9294.387
an aldehydePubChem0.930.026
coenzyme Q10PubChem0.707863.344