SInCRe - Rv0553

Tuberculist information

Gene name	menC
Protein function	Probable muconate cycloisomerase MenC (cis,cis-muconate lactonizing enzyme) (MLE)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	644.49
Molecular mass(da)	33943.2
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 326

	  		  	1    VIPVLPPLEALLDRLYVVALPMRVRFRGITTREVALIEGPAGWGEFGAFVEYQSAQACAW   60
			  	61   LASAIETAYCAPPPVRRDRVPINATVPAVAAAQVGEVLARFPGARTAKVKVAEPGQSLAD  120
			  	121  DIERVNAVRELVPMVRVDANGGWGVAEAVAAAAALTADGPLEYLEQPCATVAELAELRRR  180
			  	181  VDVPIAADESIRKAEDPLAVVRAQAADIAVLKVAPLGGISALLDIAARIAVPVVVSSALD  240
			  	241  SAVGIAAGLTAAAALPELDHACGLGTGGLFEEDVAEPAAPVDGFLAVARTTPDPARLQAL  300
			  	301  GAPPQRRQWWIDRVKACYSLLVPSFG

Known structures in the PDB

No Known structures

Number of amino acids : 326

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
MR_MLE	PF01188	124-188
MR_MLE_C	PF13378	188-287

Mtb Structural Proteome models

Model Number	1
Model name	Rv0553
Template	1SJD APDB CREDO
Template coverage	60_367
Template Identity(%)	23.8
Model coverage(%)	93.9
Normalized DOPE score	0.87

Structure Models from Chopin

Model Number	1
Profile	c.1.11.2 Click for model details
zscore	19.04
Residue begin	5
Residue end	326

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv0553	Gene name	Confidence Score
Rv0548c	menB	0.976
Rv0555	menD	0.946
Rv0555	menD	0.946
Rv0542c	menE	0.94
Rv0542c	menE	0.94
Rv0558	menH	0.923

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
4-(2'-carboxyphenyl)-4-oxobutyric acidPubChem	0.971	222.194
SHCHCPubChem	0.912	240.209
o-succinylbenzoyl-CoAPubChem	0.903	971.713
deuteriumPubChem	0.9	2.01588
protiumPubChem	0.9	2.01576
pyrophosphatePubChem	0.9	177.975
adenosine monophosphatePubChem	0.9	347.221
coenzyme APubChem	0.9	767.534
1,4-dihydroxy-2-naphthoyl-CoAPubChem	0.9	953.698
Co-APubChem	0.9	767.534
Cpo-coa esterPubChem	0.9	971.713
hydroxyl radicalsPubChem	0.9	17.0073
CPD-9925PubChem	0.9	949.666
adenosine triphosphatePubChem	0.9	507.181
H(+)PubChem	0.9	2.01588
magnesiumPubChem	0.764	24.305
SeMetPubChem	0.732	196.106
selenomethioninePubChem	0.732	196.106