Rv3215

Tuberculist information
Gene nameentC
Protein functionProbable isochorismate synthase EntC (isochorismate hydroxymutase) (enterochelin biosynthesis)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3592.25
Molecular mass(da)38905.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 372
	  		  	1    VSAHVATLHPEPPFALCGPRGTLIARGVRTRYCDVRAAQAALRSGTAPILLGALPFDVSR   60
			  	61   PAALMVPDGVLRARKLPDWPTGPLPKVRVAAALPPPADYLTRIGRARDLLAAFDGPLHKV  120
			  	121  VLARAVQLTADAPLDARVLLRRLVVADPTAYGYLVDLTSAGNDDTGAALVGASPELLVAR  180
			  	181  SGNRVMCKPFAGSAPRAADPKLDAANAAALASSAKNRHEHQLVVDTMRVALEPLCEDLTI  240
			  	241  PAQPQLNRTAAVWHLCTAITGRLRNISTTAIDLALALHPTPAVGGVPTKAATELIAELEG  300
			  	301  DRGFYAGAVGWCDGRGDGHWVVSIRCAQLSADRRAALAHAGGGIVAESDPDDELEETTTK  360
			  	361  FATILTALGVEQ

Known structures in the PDB
No Known structures
1 38 75 112 149 186 223 260 297 334 371 Range: 95 to 360  |  Coverage: 71% Chorismate_bind Range: 9 to 371  |  Coverage: 97% 1 Range: 1 to 372  |  Coverage: 99% 1
Number of amino acids : 372
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Chorismate_bindPF0042595-360
Mtb Structural Proteome models
Model Number1
Model nameRv3215
Template1QDL    APDBCREDO
Template coverage21_421
Template Identity(%)27.0
Model coverage(%)97.3
Normalized DOPE score0.124

Structure Models from Chopin
Model Number1
Profiled.161.1.1 - 3.60.120.10
Click for model details
zscore51.3
Residue begin1
Residue end372
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3215Gene nameConfidence Score
Rv0555menD0.995
Rv0555menD0.995
Rv2384mbtA0.989
Rv2384mbtA0.989
Rv2540caroF0.972
Rv3214gpm20.964
Rv2386cmbtI0.951
Rv0013trpG0.948
Rv2377cmbtH0.922
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
isochorismatePubChem0.964226.183
chorismatePubChem0.959226.183
hydroxyl radicalsPubChem0.91517.0073
SEPHCHCPubChem0.9328.271
carbon dioxidePubChem0.944.0095
AR-1G6178PubChem0.9156.136
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
pyruvic acidPubChem0.988.0621
5-enolpyruvylshikimate-3-phosphatePubChem0.9324.178
H(+)PubChem0.92.01588
C04171PubChem0.9156.136
phosphatePubChem0.996.9872
alpha-ketoglutaratePubChem0.9146.098
2,3-dihydroxybenzoic acidPubChem0.747154.12