SInCRe - Rv3853

Tuberculist information

Gene name	rraA
Protein function	Regulator of RNase E activity a RraA
Functional category(tuberculist)	regulatory proteins
Gene location(kb)	4325.5
Molecular mass(da)	16203.4
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 157

	  		  	1    VAISFRPTADLVDDIGPDVRSCDLQFRQFGGRSQFAGPISTVRCFQDNALLKSVLSQPSA   60
			  	61   GGVLVIDGAGSLHTALVGDVIAELARSTGWTGLIVHGAVRDAAALRGIDIGIKALGTNPR  120
			  	121  KSTKTGAGERDVEITLGGVTFVPGDIAYSDDDGIIVV

Known structures in the PDB

	PDB ID	1NXJ
	Total residue count	549
	Number of chains	3
	Method	X-RAY
	Resolution	1.9

Number of amino acids : 157

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Methyltransf_6	PF03737	4-156

Mtb Structural Proteome models

Model Number	1
Model name	Rv3853_1nxj_A
Template	1NXJ APDB CREDO
Template coverage	2_157
Template Identity(%)	100.0
Model coverage(%)	98.7
Normalized DOPE score	-2.065

Model Number	2
Model name	Rv3853
Template	1NXJ APDB CREDO
Template coverage	2_157
Template Identity(%)	100.0
Model coverage(%)	98.7
Normalized DOPE score	-1.784

Structure Models from Chopin

Model Number	1
Profile	c.8.7.1 - 3.50.30.40 Click for model details
zscore	36.62
Residue begin	2
Residue end	157

Binding pockets

STRING

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Protein interacting with Rv3853	Gene name	Confidence Score
Rv0534c	menA	0.949

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
glyoxylatePubChem	0.987	74.0355
tartratePubChem	0.936	150.087
octaprenyl pyrophosphatePubChem	0.9	722.911
L-tartratePubChem	0.9	148.071
deuteriumPubChem	0.9	2.01588
S-adenosyl-methioninePubChem	0.9	398.437
carbon dioxidePubChem	0.9	44.0095
S-adenosyl-L-methioninePubChem	0.9	399.445
1,4-dihydroxy-2-naphthoic acidPubChem	0.9	204.179
menaquinolPubChem	0.9	310.43
protiumPubChem	0.9	2.01576
S-adenosylhomocysteinePubChem	0.9	384.411
pyrophosphatePubChem	0.9	177.975
H(+)PubChem	0.9	2.01588
selenomethioninePubChem	0.84	196.106
magnesiumPubChem	0.751	24.305
SeMetPubChem	0.75	196.106
chloridePubChem	0.704	35.453