Rv2580c

Tuberculist information
Gene namehisS
Protein functionProbable histidyl-tRNA synthetase HisS (histidine--tRNA ligase) (HISRS) (histidine--translase)
Functional category(tuberculist)information pathways
Gene location(kb)2904.82
Molecular mass(da)45117.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 423
	  		  	1    VTEFSSFSAPKGVPDYVPPDSAQFVAVRDGLLAAARQAGYSHIELPIFEDTALFARGVGE   60
			  	61   STDVVSKEMYTFADRGDRSVTLRPEGTAGVVRAVIEHGLDRGALPVKLCYAGPFFRYERP  120
			  	121  QAGRYRQLQQVGVEAIGVDDPALDAEVIAIADAGFRSLGLDGFRLEITSLGDESCRPQYR  180
			  	181  ELLQEFLFGLDLDEDTRRRAGINPLRVLDDKRPELRAMTASAPVLLDHLSDVAKQHFDTV  240
			  	241  LAHLDALGVPYVINPRMVRGLDYYTKTAFEFVHDGLGAQSGIGGGGRYDGLMHQLGGQDL  300
			  	301  SGIGFGLGVDRTVLALRAEGKTAGDSARCDVFGVPLGEAAKLRLAVLAGRLRAAGVRVDL  360
			  	361  AYGDRGLKGAMRAAARSGARVALVAGDRDIEAGTVAVKDLTTGEQVSVSMDSVVAEVISR  420
			  	421  LAG

Known structures in the PDB
No Known structures
1 43 85 127 169 211 253 295 337 379 421 Range: 12 to 312  |  Coverage: 70% tRNA-synt_His Range: 330 to 420  |  Coverage: 21% HGTP_anticodon Range: 6 to 422  |  Coverage: 98% 1 Range: 1 to 423  |  Coverage: 99% 1 Range: 12 to 312  |  Coverage: 70% 2 Range: 330 to 420  |  Coverage: 21% 3 Range: 1 to 423  |  Coverage: 99% 4
Number of amino acids : 423
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
tRNA-synt_HisPF1339312-312
HGTP_anticodonPF03129330-420
Mtb Structural Proteome models
Model Number1
Model nameRv2580c
Template1H4V    BPDBCREDO
Template coverage2_421
Template Identity(%)40.1
Model coverage(%)98.3
Normalized DOPE score-0.096

Structure Models from Chopin
Model Number1
Profilec.51.1.1, d.104.1.1 - 3.30.930.10, 3.40.50.800
Click for model details
zscore52.81
Residue begin1
Residue end423
Model Number2
Profiled.104.1.1 - 3.30.930.10
Click for model details
zscore17.44
Residue begin12
Residue end312
Model Number3
Profile3.40.50.800
Click for model details
zscore14.6
Residue begin330
Residue end420
Model Number4
Profiled.104.1.1 - 3.30.930.10
Click for model details
zscore11.61
Residue begin1
Residue end423
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2580cGene nameConfidence Score
Rv2448cvalS0.986
Rv2448cvalS0.986
Rv2448cvalS0.986
Rv2614cthrS0.985
Rv2614cthrS0.985
Rv2614cthrS0.985
Rv2839cinfB0.979
Rv2839cinfB0.979
Rv2839cinfB0.979
Rv2839cinfB0.979
Rv2572caspS0.977
Rv2572caspS0.977
Rv2572caspS0.977
Rv2868cgcpE0.969
Rv1007cmetS0.958
Rv1292argS0.956
Rv2555calaS0.956
Rv1292argS0.956
Rv1649pheS0.956
Rv1292argS0.956
Rv1649pheS0.956
Rv2555calaS0.956
Rv2555calaS0.956
Rv3336ctrpS0.954
Rv2445cndkA0.953
Rv3834cserS0.953
Rv3834cserS0.953
Rv2121chisG0.951
Rv2121chisG0.951
Rv1606hisI0.949
Rv3628ppa0.945
Rv1599hisD0.943
Rv1699pyrG0.94
Rv0357cpurA0.94
Rv1699pyrG0.94
Rv0041leuS0.94
Rv0041leuS0.94
Rv0041leuS0.94
Rv2992cgltS0.938
Rv0667rpoB0.937
Rv0667rpoB0.937
Rv0667rpoB0.937
Rv0667rpoB0.937
Rv0667rpoB0.937
Rv0667rpoB0.937
Rv1713engA0.93
Rv1713engA0.93
Rv1689tyrS0.929
Rv1689tyrS0.929
Rv2783cgpsI0.926
Rv2783cgpsI0.926
Rv2783cgpsI0.926
Rv2783cgpsI0.926
Rv1602hisH0.926
Rv2783cgpsI0.926
Rv3598clysS0.925
Rv3598clysS0.925
Rv3458crpsD0.918
Rv3458crpsD0.918
Rv1406fmt0.915
Rv1406fmt0.915
Rv1536ileS0.914
Rv1536ileS0.914
Rv0005gyrB0.91
Rv0005gyrB0.91
Rv0005gyrB0.91
Rv0005gyrB0.91
Rv0714rplN0.909
Rv2845cproS0.909
Rv2845cproS0.909
Rv2845cproS0.909
Rv1437pgk0.908
Rv2581cRv2581c0.908
Rv1601hisB0.908
Rv0668rpoC0.907
Rv0668rpoC0.907
Rv0668rpoC0.907
Rv0668rpoC0.907
Rv0668rpoC0.907
Rv3442crpsI0.906
Rv0070cglyA20.904
Rv1299prfA0.903
Rv1093glyA10.903
Rv1299prfA0.903
Rv3455ctruA0.903
Rv3457crpoA0.902
Rv3457crpoA0.902
Rv1112Rv11120.902
Rv1112Rv11120.902
Rv3457crpoA0.902
Rv0705rpsS0.901
Rv1652argC0.901
Rv1652argC0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
L-histidinePubChem0.983155.155
Histidyl-adenosine MonophosphatePubChem0.785484.361
DB04201PubChem0.785484.361
histidylPubChem0.731261.386
SeMetPubChem0.704196.106
selenomethioninePubChem0.704196.106
HSSPubChem0.701483.459