Rv2581c

Tuberculist information
Gene nameRv2581c
Protein functionPossible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II)
Functional category(tuberculist)virulence,detoxification and adaptaion
Gene location(kb)2906.09
Molecular mass(da)24165.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 224
	  		  	1    VLITGFPAGLLACNCYVLAERPGTDAVIVDPGQGAMGTLRRILDKNRLTPAAVLLTHGHI   60
			  	61   DHIWSAQKVSDTFGCPTYVHPADRFMLTDPIYGLGPRIAQLVAGAFFREPKQVVELDRDG  120
			  	121  DKIDLGGISVNIDHTPGHTRGSVVFRVLQATNNDKDIVFTGDTLFERAIGRTDLAGGSGR  180
			  	181  DLLRSIVDKLLVLDDSTVVLPGHGNSTTIGAERRFNPFLEGLSR

Known structures in the PDB
No Known structures
1 23 45 67 89 111 133 155 177 199 221 Range: 8 to 203  |  Coverage: 87% Lactamase_B Range: 1 to 220  |  Coverage: 97% 1 Range: 1 to 223  |  Coverage: 99% 1
Number of amino acids : 224
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Lactamase_BPF007538-203
Mtb Structural Proteome models
Model Number1
Model nameRv2581c
Template2GCU    APDBCREDO
Template coverage14_215
Template Identity(%)25.7
Model coverage(%)97.8
Normalized DOPE score-0.783

Structure Models from Chopin
Model Number1
Profiled.157.1.12 - 3.60.15.10
Click for model details
zscore30.58
Residue begin1
Residue end223
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2581cGene nameConfidence Score
Rv2580chisS0.908
Rv2580chisS0.908
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions