Rv1299

Tuberculist information
Gene nameprfA
Protein functionProbable peptide chain release factor 1 PrfA (RF-1)
Functional category(tuberculist)information pathways
Gene location(kb)1455.49
Molecular mass(da)39036.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 357
	  		  	1    MTQPVQTIDVLLAEHAELELALADPALHSNPAEARRVGRRFARLAPIVATHRKLTSARDD   60
			  	61   LETARELVASDESFAAEVAALEARVGELDAQLTDMLAPRDPHDADDIVLEVKSGEGGEES  120
			  	121  ALFAADLARMYIRYAERHGWAVTVLDETTSDLGGYKDATLAIASKADTPDGVWSRMKFEG  180
			  	181  GVHRVQRVPVTESQGRVHTSAAGVLVYPEPEEVGQVQIDESDLRIDVFRSSGKGGQGVNT  240
			  	241  TDSAVRITHLPTGIVVTCQNERSQLQNKTRALQVLAARLQAMAEEQALADASADRASQIR  300
			  	301  TVDRSERIRTYNFPENRITDHRIGYKSHNLDQVLDGDLDALFDALSAADKQSRLRQS

Known structures in the PDB
No Known structures
1 36 71 106 141 176 211 246 281 316 351 Range: 59 to 179  |  Coverage: 33% PCRF Range: 209 to 322  |  Coverage: 31% RF-1 Range: 11 to 356  |  Coverage: 96% 1 Range: 1 to 357  |  Coverage: 99% 1 Range: 209 to 295  |  Coverage: 24% 2
Number of amino acids : 357
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PCRFPF0346259-179
RF-1PF00472209-322
Mtb Structural Proteome models
Model Number1
Model nameRv1299
Template1RQ0    APDBCREDO
Template coverage1_331
Template Identity(%)46.7
Model coverage(%)96.6
Normalized DOPE score0.074

Structure Models from Chopin
Model Number1
Profilee.38.1.1
Click for model details
zscore57.1
Residue begin1
Residue end357
Model Number2
Profile3.30.160.200
Click for model details
zscore14.62
Residue begin209
Residue end295
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1299Gene nameConfidence Score
Rv1300hemK0.996
Rv1298rpmE0.971
Rv2992cgltS0.968
Rv2839cinfB0.967
Rv2839cinfB0.967
Rv2839cinfB0.967
Rv2839cinfB0.967
Rv1301Rv13010.963
Rv0509hemA0.938
Rv0509hemA0.938
Rv0509hemA0.938
Rv3458crpsD0.937
Rv3458crpsD0.937
Rv3442crpsI0.934
Rv2906ctrmD0.929
Rv1406fmt0.919
Rv1297rho0.919
Rv1406fmt0.919
Rv1297rho0.919
Rv1297rho0.919
Rv2614cthrS0.918
Rv2614cthrS0.918
Rv2909crpsP0.918
Rv2614cthrS0.918
Rv0700rpsJ0.915
Rv3309cupp0.914
Rv3443crplM0.909
Rv0053rpsF0.907
Rv0683rpsG0.907
Rv2580chisS0.903
Rv2572caspS0.903
Rv2572caspS0.903
Rv2572caspS0.903
Rv2580chisS0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
UAGPubChem0.79879.608