Rv1300

Tuberculist information
Gene namehemK
Protein functionProbable HemK protein homolog HemK
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1456.56
Molecular mass(da)34589.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 325
	  		  	1    MTSAPATMRWGNLPLAGESGTMTLRQAIDLAAALLAEAGVDSARCDAEQLAAHLAGTDRG   60
			  	61   RLPLFEPPGDEFFGRYRDIVTARARRVPLQHLIGTVSFGPVVLHVGPGVFVPRPETEAIL  120
			  	121  AWATAQSLPARPLIVDACTGSGALAVALAQHRANLGLKARIIGIDDSDCALDYARRNAAG  180
			  	181  TPVELVRADVTTPRLLPELDGQVDLMVSNPPYIPDAAVLEPEVAQHDPHHALFGGPDGMT  240
			  	241  VISAVVGLAGRWLRPGGLFAVEHDDTTSSSTVDLVSSTKLFVDVQARKDLAGRPRFVTAM  300
			  	301  RWGHLPLAGENGAIDPRQRRCRAKR

Known structures in the PDB
No Known structures
1 33 65 97 129 161 193 225 257 289 321 Range: 110 to 244  |  Coverage: 41% Methyltransf_26 Range: 22 to 302  |  Coverage: 86% 1 Range: 131 to 265  |  Coverage: 41% 1
Number of amino acids : 325
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Methyltransf_26PF13659110-244
Mtb Structural Proteome models
Model Number1
Model nameRv1300
Template2B3T    APDBCREDO
Template coverage1_276
Template Identity(%)27.2
Model coverage(%)86.2
Normalized DOPE score0.106

Structure Models from Chopin
Model Number1
Profilec.66.1.30
Click for model details
zscore28.35
Residue begin131
Residue end265
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1300Gene nameConfidence Score
Rv1299prfA0.996
Rv1299prfA0.996
Rv1301Rv13010.976
Rv3105cprfB0.953
Rv3105cprfB0.953
Rv1298rpmE0.937
Rv0509hemA0.925
Rv0509hemA0.925
Rv0509hemA0.925
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
protoporphyrinogen IXPubChem0.907568.706
molecular oxygenPubChem0.931.9988
protoporphyrinPubChem0.9562.658
hydrogen peroxidePubChem0.934.0147
S-adenosylhomocysteinePubChem0.76384.411
S-adenosyl-L-methioninePubChem0.711399.445