Rv3105c

Tuberculist information
Gene nameprfB
Protein functionProbable peptide chain release factor 2 PrfB (RF-2)
Functional category(tuberculist)information pathways
Gene location(kb)3472.77
Molecular mass(da)42125
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 378
	  		  	1    MPVTLAAVDPDRQADIAALDCTLTTVERVLDVEGLRSRIEKLEHEASDPHLWDDQTRAQR   60
			  	61   VTSELSHTQGELRRVEELRRRLDDLPVLYELAAEEAGAAAADAVAEADAELKSLRADIEA  120
			  	121  TEVRTLLSGEYDEREALVTIRSGAGGVDAADWAEMLMRMYIRWAEQHKYPVEVFDTSYAE  180
			  	181  EAGIKSATFAVHAPFAYGTLSVEQGTHRLVRISPFDNQSRRQTSFAEVEVLPVVETTDHI  240
			  	241  DIPEGDVRVDVYRSSGPGGQSVNTTDSAVRLTHIPSGIVVTCQNEKSQLQNKIAAMRVLQ  300
			  	301  AKLLERKRLEERAELDALKADGGSSWGNQMRSYVLHPYQMVKDLRTEYEVGNPAAVLDGD  360
			  	361  LDGFLEAGIRWRNRRNDD

Known structures in the PDB
No Known structures
1 38 75 112 149 186 223 260 297 334 371 Range: 83 to 196  |  Coverage: 29% PCRF Range: 226 to 338  |  Coverage: 29% RF-1 Range: 15 to 375  |  Coverage: 95% 1 Range: 9 to 378  |  Coverage: 97% 1 Range: 233 to 319  |  Coverage: 22% 2
Number of amino acids : 378
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PCRFPF0346283-196
RF-1PF00472226-338
Mtb Structural Proteome models
Model Number1
Model nameRv3105c
Template2B9M    YPDBCREDO
Template coverage2_355
Template Identity(%)44.1
Model coverage(%)95.2
Normalized DOPE score2.242

Structure Models from Chopin
Model Number1
Profilee.38.1.1
Click for model details
zscore65.25
Residue begin9
Residue end378
Model Number2
Profile3.30.160.200
Click for model details
zscore16.21
Residue begin233
Residue end319
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3105cGene nameConfidence Score
Rv1300hemK0.953
Rv3598clysS0.927
Rv3598clysS0.927
Rv2882cfrr0.911
Rv0700rpsJ0.907
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions