Rv1112

Tuberculist information
Gene nameRv1112
Protein functionProbable GTP binding protein
Functional category(tuberculist)conserved hypotheticals
Gene location(kb)1238.26
Molecular mass(da)38065.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 357
	  		  	1    VSLSLGIVGLPNVGKSTLFNALTRNNVVAANYPFATIEPNEGVVSLPDPRLDKLAELFGS   60
			  	61   QRVVPAPVTFVDIAGLVKGASEGAGLGNKFLAHIRECDAICQVVRVFVDDDVTHVTGRVD  120
			  	121  PQSDIEVVETELILADLQTLERATGRLEKEARTNKARKPVYDAALRAQQVLDAGKTLFAA  180
			  	181  GVDAAALRELNLLTTKPFLYVFNADEAVLTDPARVGELRALVAPADAVFLDAAIESELTE  240
			  	241  LDDESAAELLESIGQSERGLDALARAGFHTLKLQTFLTAGPKEARAWTIHQGDTAPKAAG  300
			  	301  VIHSDFEKGFIKAEIVSYDDLVAAGSMAAAKAAGKVRIEGKDYVMADGDVVEFRFNV

Known structures in the PDB
No Known structures
1 36 71 106 141 176 211 246 281 316 351 Range: 4 to 204  |  Coverage: 56% MMR_HSR1 Range: 273 to 356  |  Coverage: 23% YchF-GTPase_C Range: 3 to 355  |  Coverage: 98% 1 Range: 1 to 357  |  Coverage: 99% 1 Range: 273 to 357  |  Coverage: 23% 2 Range: 116 to 196  |  Coverage: 22% 3
Number of amino acids : 357
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
MMR_HSR1PF019264-204
YchF-GTPase_CPF06071273-356
Mtb Structural Proteome models
Model Number1
Model nameRv1112
Template2DBY    APDBCREDO
Template coverage2_366
Template Identity(%)54.4
Model coverage(%)98.6
Normalized DOPE score-0.173

Structure Models from Chopin
Model Number1
Profilec.37.1.8, d.15.10.2 - 1.10.150.300, 3.10.20.30, 3.40.50.300
Click for model details
zscore64.55
Residue begin1
Residue end357
Model Number2
Profiled.15.10.2
Click for model details
zscore20.42
Residue begin273
Residue end357
Model Number3
Profile1.10.150.300
Click for model details
zscore12.16
Residue begin116
Residue end196
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1112Gene nameConfidence Score
Rv2992cgltS0.991
Rv1649pheS0.987
Rv1649pheS0.987
Rv1007cmetS0.987
Rv1014cpth0.986
Rv2839cinfB0.977
Rv2839cinfB0.977
Rv2839cinfB0.977
Rv2839cinfB0.977
Rv1017cprsA0.974
Rv1017cprsA0.974
Rv1010ksgA0.97
Rv3834cserS0.969
Rv3834cserS0.969
Rv1712cmk0.966
Rv2614cthrS0.955
Rv2614cthrS0.955
Rv2614cthrS0.955
Rv2404clepA0.953
Rv2404clepA0.953
Rv2404clepA0.953
Rv2404clepA0.953
Rv3396cguaA0.942
Rv3396cguaA0.942
Rv3396cguaA0.942
Rv0640rplK0.938
Rv0640rplK0.938
Rv2448cvalS0.933
Rv2448cvalS0.933
Rv2448cvalS0.933
Rv0716rplE0.931
Rv0716rplE0.931
Rv1310atpD0.916
Rv0683rpsG0.916
Rv1310atpD0.916
Rv1310atpD0.916
Rv0056rplI0.915
Rv0056rplI0.915
Rv0641rplA0.913
Rv0041leuS0.905
Rv0041leuS0.905
Rv0041leuS0.905
Rv2580chisS0.902
Rv2580chisS0.902
Rv1438tpi0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
AMP-PCPPubChem0.904505.208
ATP analogPubChem0.845505.208
SeMetPubChem0.768196.106
selenomethioninePubChem0.768196.106
guanosine diphosphatePubChem0.704443.201
formatePubChem0.70445.0174