Rv1438

Tuberculist information
Gene nametpi
Protein functionProbable triosephosphate isomerase Tpi (TIM)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1615.56
Molecular mass(da)27371
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 261
	  		  	1    VSRKPLIAGNWKMNLNHYEAIALVQKIAFSLPDKYYDRVDVAVIPPFTDLRSVQTLVDGD   60
			  	61   KLRLTYGAQDLSPHDSGAYTGDVSGAFLAKLGCSYVVVGHSERRTYHNEDDALVAAKAAT  120
			  	121  ALKHGLTPIVCIGEHLDVREAGNHVAHNIEQLRGSLAGLLAEQIGSVVIAYEPVWAIGTG  180
			  	181  RVASAADAQEVCAAIRKELASLASPRIADTVRVLYGGSVNAKNVGDIVAQDDVDGGLVGG  240
			  	241  ASLDGEHFATLAAIAAGGPLP

Known structures in the PDB
PDB ID3GVG
Total residue count566
Number of chains2
MethodX-RAY
Resolution1.55
PDB ID3TA6
Total residue count534
Number of chains2
MethodX-RAY
Resolution1.41
PDB ID3TAO
Total residue count534
Number of chains2
MethodX-RAY
Resolution1.45
1 27 53 79 105 131 157 183 209 235 261 Range: 5 to 252  |  Coverage: 94% TIM Range: 2 to 257  |  Coverage: 97% 1 Range: 3 to 255  |  Coverage: 96% 2 Range: 1 to 261  |  Coverage: 99% 1
Number of amino acids : 261
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
TIMPF001215-252
Mtb Structural Proteome models
Model Number1
Model nameRv1438_3gvg_A
Template3GVG    APDBCREDO
Template coverage2_257
Template Identity(%)100.0
Model coverage(%)97.7
Normalized DOPE score-2.056

Model Number2
Model nameRv1438
Template1YYA    APDBCREDO
Template coverage2_249
Template Identity(%)50.0
Model coverage(%)96.6
Normalized DOPE score-1.083

Structure Models from Chopin
Model Number1
Profilec.1.1.1 - 3.20.20.70
Click for model details
zscore51.45
Residue begin1
Residue end261
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1438Gene nameConfidence Score
Rv1437pgk0.999
Rv0363cfba0.999
Rv1436gap0.999
Rv1436gap0.999
Rv1023eno0.997
Rv1023eno0.997
Rv0946cpgi0.996
Rv1617pykA0.993
Rv1617pykA0.993
Rv0489gpm10.985
Rv0478deoC0.98
Rv1449ctkt0.975
Rv1449ctkt0.975
Rv1449ctkt0.975
Rv3010cpfkA0.97
Rv2445cndkA0.965
Rv1448ctal0.96
Rv2584capt0.951
Rv3846sodA0.951
Rv3846sodA0.951
Rv1240mdh0.944
Rv1240mdh0.944
Rv2783cgpsI0.94
Rv2783cgpsI0.94
Rv2783cgpsI0.94
Rv2783cgpsI0.94
Rv2783cgpsI0.94
Rv1389gmk0.922
Rv0952sucD0.915
Rv0952sucD0.915
Rv1392metK0.907
Rv1392metK0.907
Rv1392metK0.907
Rv0350dnaK0.905
Rv0409ackA0.904
Rv3914trxC0.902
Rv2889ctsf0.901
Rv2889ctsf0.901
Rv1112Rv11120.901
Rv1112Rv11120.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
dihydroxyacetone phosphatePubChem0.996170.058
D-glyceraldehyde-3-phosphatePubChem0.993170.058
phosphatePubChem0.99196.9872
glycerolPubChem0.99192.0938
3-phosphoglyceratePubChem0.984186.057
glyceraldehyde-3-phosphatePubChem0.966170.058
fructose 1,6-bisphosphatePubChem0.964340.116
sulfatePubChem0.94296.0626
NADPPubChem0.937744.413
D-fructose 1,6-bisphosphatePubChem0.933550.183
NAD+PubChem0.932663.425
1,3-bisphosphoglyceratePubChem0.925266.037
1,3-diphosphoglyceratePubChem0.922266.037
deuteriumPubChem0.9192.01588
phosphoglycolatePubChem0.91156.031
hydroxyl radicalsPubChem0.9117.0073
phosphoglycolohydroxamatePubChem0.908171.046
H(+)PubChem0.9072.01588
reduced nicotinamide adenine dinucleotidePubChem0.903665.441
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
1,3-bisphospho-d-glyceratePubChem0.9266.037
protiumPubChem0.92.01576
NADP(H)PubChem0.9745.421
phosphoglyceratePubChem0.842186.057
hydron sulfatePubChem0.8196.157
hydron diphosphatePubChem0.798391.981
methyl jasmonatePubChem0.797224.296
phosphitePubChem0.79378.972
MeJAPubChem0.792224.296
acetatePubChem0.76859.044
magnesiumPubChem0.71624.305
polyethylene glycolPubChem0.71562.0678
Na(+)PubChem0.70322.9898
beta-glycerophosphatePubChem0.701172.074
nitratePubChem0.762.0049
ethylene glycol; hydronPubChem0.763.0758