Rv0478

Tuberculist information
Gene namedeoC
Protein functionProbable deoxyribose-phosphate aldolase DeoC (phosphodeoxyriboaldolase) (deoxyriboaldolase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)567.222
Molecular mass(da)22036.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 224
	  		  	1    VLGQPTRAQLAALVDHTLLKPETTRADVAALVAEAAELGVYAVCVSPSMVPVAVQAGGVR   60
			  	61   VAAVTGFPSGKHVSSVKAHEAAAALASGASEIDMVIDIGAALCGDIDAVRSDIEAVRAAA  120
			  	121  AGAVLKVIVESAVLLGQSNAHTLVDACRAAEDAGADFVKTSTGCHPAGGATVRAVELMAE  180
			  	181  TVGPRLGVKASGGIRTAADAVAMLNAGATRLGLSGTRAVLDGLS

Known structures in the PDB
No Known structures
1 23 45 67 89 111 133 155 177 199 221 Range: 9 to 222  |  Coverage: 95% DeoC Range: 10 to 220  |  Coverage: 93% 1 Range: 1 to 224  |  Coverage: 99% 1
Number of amino acids : 224
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
DeoCPF017919-222
Mtb Structural Proteome models
Model Number1
Model nameRv0478
Template1UB3    APDBCREDO
Template coverage3_211
Template Identity(%)45.0
Model coverage(%)93.8
Normalized DOPE score-0.579

Structure Models from Chopin
Model Number1
Profilec.1.10.1 - 3.20.20.70
Click for model details
zscore9.66
Residue begin1
Residue end224
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0478Gene nameConfidence Score
Rv2436rbsK0.995
Rv1438tpi0.98
Rv1449ctkt0.98
Rv1449ctkt0.98
Rv1449ctkt0.98
Rv0477Rv04770.978
Rv3314cdeoA0.977
Rv3314cdeoA0.977
Rv3314cdeoA0.977
Rv0476Rv04760.976
Rv3309cupp0.972
Rv3308pmmB0.968
Rv3308pmmB0.968
Rv3308pmmB0.968
Rv3308pmmB0.968
Rv1023eno0.958
Rv1023eno0.958
Rv3315ccdd0.955
Rv0363cfba0.939
Rv1448ctal0.936
Rv1617pykA0.934
Rv1617pykA0.934
Rv0650Rv06500.903
Rv3307deoD0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
acetaldehydePubChem0.94444.0526
D-glyceraldehyde-3-phosphatePubChem0.943170.058
deoxyribose 5-phosphatePubChem0.924214.11
2-deoxy-d-ribose-5-phosphatePubChem0.923214.11
glyceraldehyde-3-phosphatePubChem0.904170.058
deoxyribose-1-phosphatePubChem0.9214.11
2-deoxy-D-ribose-1-phosphatePubChem0.9214.11
polyethylene glycolPubChem0.78862.0678
ethylene glycol; hydronPubChem0.78863.0758
zincPubChem0.78465.409
DB04087PubChem0.77216.126
1-hydroxy-pentane-3,4-diol-5-phosphatePubChem0.77216.126
phosphatePubChem0.72596.9872
Na(+)PubChem0.72222.9898