Rv3315c

Tuberculist information
Gene namecdd
Protein functionProbable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3703.46
Molecular mass(da)14072.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 133
	  		  	1    MPDVDWNMLRGNATQAAAGAYVPYSRFAVGAAALVDDGRVVTGCNVENVSYGLTLCAECA   60
			  	61   VVCALHSTGGGRLLALACVDGHGSVLMPCGRCRQVLLEHGGSELLIDHPVRPRRLGDLLP  120
			  	121  DAFGLDDLPRERR

Known structures in the PDB
PDB ID3IJF
Total residue count133
Number of chains1
MethodX-RAY
Resolution1.99
1 14 27 40 53 66 79 92 105 118 131 Range: 4 to 108  |  Coverage: 78% dCMP_cyt_deam_1 Range: 3 to 125  |  Coverage: 91% 1 Range: 7 to 130  |  Coverage: 92% 2 Range: 1 to 130  |  Coverage: 96% 1
Number of amino acids : 133
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
dCMP_cyt_deam_1PF003834-108
Mtb Structural Proteome models
Model Number1
Model nameRv3315c_3ijf_X
Template3IJF    XPDBCREDO
Template coverage3_125
Template Identity(%)100.0
Model coverage(%)91.7
Normalized DOPE score-0.851

Model Number2
Model nameRv3315c
Template2FR5    APDBCREDO
Template coverage16_144
Template Identity(%)39.5
Model coverage(%)92.5
Normalized DOPE score0.109

Structure Models from Chopin
Model Number1
Profilec.97.1.1 - 3.40.140.10
Click for model details
zscore30.51
Residue begin1
Residue end130
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3315cGene nameConfidence Score
Rv3314cdeoA0.999
Rv3314cdeoA0.999
Rv3314cdeoA0.999
Rv3313cadd0.994
Rv3307deoD0.989
Rv3309cupp0.987
Rv0478deoC0.955
Rv2367cRv2367c0.94
Rv1699pyrG0.923
Rv1699pyrG0.923
Rv0321dcd0.905
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
zincPubChem0.99965.409
cytidinePubChem0.996243.217
cytosine arabinosidePubChem0.995243.217
uridinePubChem0.993244.201
deoxycytidinePubChem0.991227.217
deoxyuridinePubChem0.986228.202
phosphatePubChem0.96896.9872
ammoniaPubChem0.96717.0305
uracilPubChem0.96112.087
dUMPPubChem0.94308.182
polyuridylic acidPubChem0.93324.181
2-deoxy-alpha-D-ribose 1-phosphatePubChem0.924214.11
hydroxyl radicalsPubChem0.91317.0073
zebularinePubChem0.913228.202
deoxyribose-1-phosphatePubChem0.91214.11
guanosine triphosphatePubChem0.905523.18
H(+)PubChem0.9052.01588
deuteriumPubChem0.9052.01588
ribose 1-phosphatePubChem0.9230.11
CHEBI:16450PubChem0.9228.202
guanosine diphosphatePubChem0.9443.201
protiumPubChem0.92.01576
ArabinosylcytosinPubChem0.9243.217
adenosine diphosphatePubChem0.9427.201
adenosine triphosphatePubChem0.9507.181
tetrahydrouridinePubChem0.892248.233
diazepinone ribosidePubChem0.878244.244
chloridePubChem0.81435.453
blasticidin SPubChem0.806422.439
cytosinePubChem0.778111.102
Coaracine (racemic)PubChem0.776262.26
NSC322096PubChem0.774244.244
CNDACPubChem0.768252.227
CHEBI:707231PubChem0.76244.244
tetrahydrodeoxyuridinePubChem0.751230.218
H4 UPubChem0.746248.233
CHEBI:705359PubChem0.743262.26
DAUPubChem0.718243.213
dCMPPubChem0.713307.197
Nsc322095PubChem0.705246.26
CHEBI:705347PubChem0.701248.233