Rv0650

Tuberculist information
Gene nameRv0650
Protein functionPossible sugar kinase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)747.037
Molecular mass(da)29269.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 302
	  		  	1    MLTLCLDIGGTKIAAGLADPAGTLVHTAQRPTPAYGGAEQVWAAVAEMIADALGVAGGAV   60
			  	61   GGVGIASAGPIDLHSGRVSPINIGSWGGFPLRDRVAAAVPGVPVRLGGDGVCMALGEHWL  120
			  	121  GAGRGARFLLGLVVSTGVGGGLVLDGAPCLGRTGNAGHVGHVVVDPDGSPCPCGGRGCVE  180
			  	181  TIASGPSLARWARANGWSAPPGAGAKELAEAAGAGDPVALRAFRRGAAALAAMIASVGAV  240
			  	241  CDLDLAVIGGGVAKSGRLLFEPLRAALADHARLDFLAGLRVVPAELGGAAGLVGAARLAA  300
			  	301  IA

Known structures in the PDB
No Known structures
1 31 61 91 121 151 181 211 241 271 301 Range: 5 to 188  |  Coverage: 60% ROK Range: 1 to 299  |  Coverage: 98% 1 Range: 123 to 299  |  Coverage: 58% 1 Range: 1 to 108  |  Coverage: 35% 2
Number of amino acids : 302
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ROKPF004805-188
Mtb Structural Proteome models
Model Number1
Model nameRv0650
Template2AA4    APDBCREDO
Template coverage1_286
Template Identity(%)35.7
Model coverage(%)98.7
Normalized DOPE score-0.097

Structure Models from Chopin
Model Number1
Profilec.55.1.10
Click for model details
zscore14.93
Residue begin123
Residue end299
Model Number2
Profilec.55.1.5
Click for model details
zscore10.3
Residue begin1
Residue end108
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0650Gene nameConfidence Score
Rv3068cpgmA0.966
Rv3068cpgmA0.966
Rv3068cpgmA0.966
Rv3068cpgmA0.966
Rv0946cpgi0.955
Rv1449ctkt0.937
Rv1449ctkt0.937
Rv1449ctkt0.937
Rv3257cpmmA0.929
Rv3257cpmmA0.929
Rv3257cpmmA0.929
Rv3257cpmmA0.929
Rv0478deoC0.903
Rv2702ppgK0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
galactosePubChem0.951180.156
alpha-D-glucosePubChem0.934198.171
glucose-6-phosphatePubChem0.931260.136
alpha-D-glucose 6-phosphatePubChem0.9260.136
glucose-6-PPubChem0.9260.136
zincPubChem0.74665.409
magnesiumPubChem0.73424.305