Rv0409

Tuberculist information
Gene nameackA
Protein functionProbable acetate kinase AckA (acetokinase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)493.851
Molecular mass(da)41318.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 385
	  		  	1    MSSTVLVINSGSSSLKFQLVEPVAGMSRAAGIVERIGERSSPVADHAQALHRAFKMLAED   60
			  	61   GIDLQTCGLVAVGHRVVHGGTEFHQPTLLDDTVIGKLEELSALAPLHNPPAVLGIKVARR  120
			  	121  LLANVAHVAVFDTAFFHDLPPAAATYAIDRDVADRWHIRRYGFHGTSHQYVSERAAAFLG  180
			  	181  RPLDGLNQIVLHLGNGASASAIARGRPVETSMGLTPLEGLVMGTRSGDLDPGVISYLWRT  240
			  	241  ARMGVEDIESMLNHRSGMLGLAGERDFRRLRLVIETGDRSAQLAYEVFIHRLRKYLGAYL  300
			  	301  AVLGHTDVVSFTAGIGENDAAVRRDALAGLQGLGIALDQDRNLGPGHGARRISSDDSPIA  360
			  	361  VLVVPTNEELAIARDCLRVLGGRRA

Known structures in the PDB
No Known structures
1 39 77 115 153 191 229 267 305 343 381 Range: 4 to 374  |  Coverage: 96% Acetate_kinase Range: 4 to 381  |  Coverage: 97% 1 Range: 182 to 385  |  Coverage: 52% 1
Number of amino acids : 385
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acetate_kinasePF008714-374
Mtb Structural Proteome models
Model Number1
Model nameRv0409
Template1G99    APDBCREDO
Template coverage2_397
Template Identity(%)45.2
Model coverage(%)97.9
Normalized DOPE score-0.59

Structure Models from Chopin
Model Number1
Profilec.55.1.2
Click for model details
zscore18.8
Residue begin182
Residue end385
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0409Gene nameConfidence Score
Rv0408pta0.999
Rv0408pta0.999
Rv0408pta0.999
Rv3667acs0.993
Rv3667acs0.993
Rv1617pykA0.979
Rv1617pykA0.979
Rv0147Rv01470.971
Rv0458Rv04580.962
Rv2858caldC0.96
Rv0768aldA0.96
Rv1437pgk0.941
Rv1020mfd0.92
Rv1020mfd0.92
Rv1020mfd0.92
Rv1020mfd0.92
Rv0467icl10.917
Rv0946cpgi0.914
Rv2965ckdtB0.905
Rv1438tpi0.904
Rv1127cppdK0.903
Rv0363cfba0.903
Rv1127cppdK0.903
Rv3535chsaG0.901
Rv3535chsaG0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
acetatePubChem0.99359.044
acetyl-CoAPubChem0.987809.571
acetyl phosphatePubChem0.979140.032
butyryl-CoAPubChem0.976837.624
butyratePubChem0.97388.1051
coenzyme APubChem0.968767.534
propionyl phosphatePubChem0.967154.058
phosphatePubChem0.96596.9872
adenosine triphosphatePubChem0.961507.181
adenosine diphosphatePubChem0.959427.201
pyrophosphatePubChem0.924177.975
Co-APubChem0.915767.534
deuteriumPubChem0.92.01588
butyryl phosphatePubChem0.9168.085
H(+)PubChem0.92.01588
protiumPubChem0.92.01576
adenosine monophosphatePubChem0.9347.221
[(2S,5S)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[[[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-[2-(1-oPubChem0.9833.592
acetyl coenzyme-APubChem0.9809.571
phenylglyoxalPubChem0.877134.132
diethyl pyrocarbonatePubChem0.865162.141
isobutyratePubChem0.81788.1051
acetate asPubChem0.758404.497
lactatePubChem0.75290.0779
propionatePubChem0.74674.0785
ethylene glycol; hydronPubChem0.72563.0758
polyethylene glycolPubChem0.72562.0678
propionyl-CoAPubChem0.721823.597
xylosePubChem0.72150.13
ethanolPubChem0.7246.0684
formatePubChem0.7245.0174
alpha-ketobutyratePubChem0.706102.089