Rv1020

Tuberculist information
Gene namemfd
Protein functionProbable transcription-repair coupling factor Mfd (TRCF)
Functional category(tuberculist)information pathways
Gene location(kb)1138.97
Molecular mass(da)132908
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 1234
	  		  	1    MTAPGPACSDTPIAGLVELALSAPTFQQLMQRAGGRPDELTLIAPASARLLVASALARQG   60
			  	61   PLLVVTATGREADDLAAELRGVFGDAVALLPSWETLPHERLSPGVDTVGTRLMALRRLAH  120
			  	121  PDDAQLGPPLGVVVTSVRSLLQPMTPQLGMMEPLTLTVGDESPFDGVVARLVELAYTRVD  180
			  	181  MVGRRGEFAVRGGILDIFAPTAEHPVRVEFWGDEITEMRMFSVADQRSIPEIDIHTLVAF  240
			  	241  ACRELLLSEDVRARAAQLAARHPAAESTVTGSASDMLAKLAEGIAVDGMEAVLPVLWSDG  300
			  	301  HALLTDQLPDGTPVLVCDPEKVRTRAADLIRTGREFLEASWSVAALGTAENQAPVDVEQL  360
			  	361  GGSGFVELDQVRAAAARTGHPWWTLSQLSDESAIELDVRAAPSARGHQRDIDEIFAMLRA  420
			  	421  HIATGGYAALVAPGTGTAHRVVERLSESDTPAGMLDPGQAPKPGVVGVLQGPLRDGVIIP  480
			  	481  GANLVVITETDLTGSRVSAAEGKRLAAKRRNIVDPLALTAGDLVVHDQHGIGRFVEMVER  540
			  	541  TVGGARREYLVLEYASAKRGGGAKNTDKLYVPMDSLDQLSRYVGGQAPALSRLGGSDWAN  600
			  	601  TKTKARRAVREIAGELVSLYAKRQASPGHAFSPDTPWQAELEDAFGFTETVDQLTAIEEV  660
			  	661  KADMEKPIPMDRVICGDVGYGKTEIAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFGER  720
			  	721  MSGFPVTIKGLSRFTDAAESRAVIDGLADGSVDIVIGTHRLLQTGVRWKDLGLVVVDEEQ  780
			  	781  RFGVEHKEHIKSLRTHVDVLTMSATPIPRTLEMSLAGIREMSTILTPPEERYPVLTYVGP  840
			  	841  HDDKQIAAALRRELLRDGQAFYVHNRVSSIDAAAARVRELVPEARVVVAHGQMPEDLLET  900
			  	901  TVQRFWNREHDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLRGRVGRSRERGYA  960
			  	961  YFLYPPQVPLTETAYDRLATIAQNNELGAGMAVALKDLEIRGAGNVLGIEQSGHVAGVGF 1020
			  	1021 DLYVRLVGEALETYRDAYRAAADGQTVRTAEEPKDVRIDLPVDAHLPPDYIASDRLRLEG 1080
			  	1081 YRRLAAASSDREVAAVVDELTDRYGALPEPARRLAAVARLRLLCRGSGITDVTAASAATV 1140
			  	1141 RLSPLTLPDSAQVRLKRMYPGAHYRATTATVQVPIPRAGGLGAPRIRDVELVQMVADLIT 1200
			  	1201 ALAGKPRQHIGITNPSPPGEDGRGRNTTIKERQP

Known structures in the PDB
No Known structures
1 124 247 370 493 616 739 862 985 1108 1231 Range: 517 to 621  |  Coverage: 8% CarD_CdnL_TRCF Range: 650 to 814  |  Coverage: 13% DEAD Range: 880 to 955  |  Coverage: 6% Helicase_C Range: 1059 to 1156  |  Coverage: 7% TRCF Range: 26 to 182  |  Coverage: 12% 1 Range: 1 to 1207  |  Coverage: 97% 1 Range: 1059 to 1156  |  Coverage: 7% 2 Range: 507 to 593  |  Coverage: 6% 3 Range: 1044 to 1201  |  Coverage: 12% 4 Range: 625 to 1164  |  Coverage: 43% 5 Range: 532 to 878  |  Coverage: 28% 6 Range: 825 to 967  |  Coverage: 11% 7
Number of amino acids : 1234
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
CarD_CdnL_TRCFPF02559517-621
DEADPF00270650-814
Helicase_CPF00271880-955
TRCFPF034611059-1156
Mtb Structural Proteome models
Model Number1
Model nameRv1020
Template2EYQ    APDBCREDO
Template coverage5_1147
Template Identity(%)35.2
Model coverage(%)95.7
Normalized DOPE score0.233

Structure Models from Chopin
Model Number1
Profileb.34.18.1, c.37.1.19, d.315.1.1
Click for model details
zscore125.34
Residue begin1
Residue end1207
Model Number2
Profiled.315.1.1
Click for model details
zscore25.96
Residue begin1059
Residue end1156
Model Number3
Profileb.34.18.1
Click for model details
zscore21.04
Residue begin507
Residue end593
Model Number4
Profiled.315.1.1
Click for model details
zscore17.36
Residue begin1044
Residue end1201
Model Number5
Profilea.4.5.43, c.37.1.19 - 1.10.10.10, 3.40.50.300
Click for model details
zscore16.71
Residue begin625
Residue end1164
Model Number6
Profilec.37.1.19 - 3.40.50.300
Click for model details
zscore14.62
Residue begin532
Residue end878
Model Number7
Profilec.37.1.14 - 3.40.50.300
Click for model details
zscore8.05
Residue begin825
Residue end967
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1020Gene nameConfidence Score
Rv1638uvrA0.998
Rv2555calaS0.982
Rv2555calaS0.982
Rv2555calaS0.982
Rv1021Rv10210.965
Rv0003recF0.958
Rv1696recN0.952
Rv0667rpoB0.946
Rv0667rpoB0.946
Rv0667rpoB0.946
Rv0667rpoB0.946
Rv0667rpoB0.946
Rv0667rpoB0.946
Rv1420uvrC0.942
Rv1420uvrC0.942
Rv1420uvrC0.942
Rv1420uvrC0.942
Rv3674cnth0.94
Rv3674cnth0.94
Rv3674cnth0.94
Rv2592cruvB0.936
Rv2592cruvB0.936
Rv1017cprsA0.929
Rv1017cprsA0.929
Rv2593cruvA0.926
Rv2593cruvA0.926
Rv2593cruvA0.926
Rv0409ackA0.92
Rv0001dnaA0.919
Rv0001dnaA0.919
Rv2594cruvC0.915
Rv1629polA0.903
Rv1629polA0.903
Rv1629polA0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions